Why is cefazolin used for surgical prophylaxis?
Cefazolin is the most commonly used antibiotic for prophylaxis. It offers the advantages of a moderately long half-life, activity against most staphylococci and streptococci (in addition to some gram-negative aerobic organisms), and low cost.
When should I take cefazolin before surgery?
Cefazolin is the most commonly used antibiotic drug in arthroplasty antibiotic prophylaxis worldwide. Guidelines and studies recommend that prophylactic antibiotics should be completely infused within 60 min before the surgical incision.
Which surgeries require prophylactic antibiotics?
Prophylaxis is indicated for cesarean section and abdominal and vaginal hysterectomy. Numerous clinical trials have demonstrated a reduction in risk of wound infection or endometritis by as much as 70 percent in patients undergoing cesarean section.
Which cephalosporin is used for surgical prophylaxis?
Cephalosporins are considered to be the drug of choice, because they offer fewer allergic reactions. From the first generation cephalosporins, cefazolin has been widely recommended with success.
Why metronidazole and cefazolin are commonly given together?
Conclusion: Antibiotic prophylaxis with metronidazole and cefazolin results in fewer postoperative infections, decreased duration of hospitalization, and lower medication cost than cefazolin alone.
When are prophylactic antibiotics used?
Prophylactic antibiotics are antibiotics that you take to prevent infection. Normally, you take antibiotics when you have an infection. Your doctor may give you antibiotics ahead of time to prevent infection in some situations where your risk of infection is high.
How is cefazolin given?
Cefazolin injection comes as a powder to be mixed with liquid, or as a premixed product, to be injected intravenously (into a vein) over a period of 30 minutes. Cefazolin injection can also be given intramuscularly (into a muscle). It is usually given every 6, 8, or 12 hours.
What is the primary reason for giving prophylactic antibiotics to patient who will undergo colorectal surgery?
Research shows that administration of prophylactic antibiotics before colorectal surgery prevents postoperative surgical wound infection.
Cefazolin remains the drug of choice for surgical prophylaxis in many procedures due to its favourable safety profile, low cost and targeted activity against the microorganisms commonly encountered during surgical procedures [4].
What is the recommended dose of cefazolin for surgery?
Background Most surgical prophylaxis guidelines recommend a 3-g cefazolin intravenous dose in patients weighing ≥ 120 kg. However, this recommendation is primarily based on pharmacokinetic studies rather than robust clinical evidence.
What is the role of cefazolin in the treatment of beta-lactam allergy?
Cefazolin is used most often for surgical prophylaxis in patients with no history of beta-lactam allergy, a history of MRSA infection, or when consideration is given to surgical sites in which the most probable organisms that are not covered by cefazolin alone (e.g., appendectomy, colorectal).
What are the ACOG guidelines on cefazolin for obesity?
The American Journal of Obstetricians and Gynaecologists (ACOG) Practice Bulletin and the Australian Therapeutic Guidelines (TG) also suggest the need for a higher prophylactic cefazolin dose for obese surgical patients but do not specify the recommended dose or weight or BMI cut-off values [6, 7].