Which drug is better for prophylaxis of migraine?
Sufficient evidence and consensus exist to recommend propranolol, timolol, amitriptyline, divalproex, sodium valproate, and topiramate as first-line agents for migraine prevention. There is fair evidence of effectiveness with gabapentin and naproxen sodium.
Which beta blocker is contraindicated in migraine prophylaxis?
Dosing Recommendations for First- and Second-Line Medications for Episodic Migraine Prevention
| Drug | Starting dose | Contraindications |
|---|---|---|
| Beta blockers | ||
| Atenolol | 50 mg | Asthma, brady-cardia, COPD |
| Metoprolol | 50 mg two times daily | Asthma, brady-cardia, COPD |
| Nadolol (Corgard) | 40 to 80 mg | Asthma, brady-cardia, COPD |
Why is propranolol used for migraine prophylaxis?
Propranolol is a beta blocker that is sometimes prescribed for the prevention of migraines. It may work by preventing the dilation of blood vessels and stabilizing serotonin levels. If propranolol works for you, your migraine attacks will be shorter, less intense, and less frequent.
When should migraine prophylaxis be stopped?
Preventive migraine therapy should be stopped when: The patient develops intolerable adverse events or a severe drug reaction. The drug does not demonstrate even partial efficacy after 2 months of therapy and disorders such as acute medication overuse have been eliminated.
Can diltiazem be used for migraines?
This treatment is approved only for people who have headaches at least 15 days a month. The more often you have migraines, the better Botox seems to help. Calcium-channel blockers. These include diltiazem (Cardizem, Cartia, Tiazac) and verapamil (Calan, Covera HS, Verelan).
Can metoprolol be used for migraines?
Background: Beta-blockers such as propranolol and metoprolol are known to be effective in preventing migraine attacks.
Can bisoprolol be used for migraines?
Bisoprolol is one of the beta blockers that has scientific evidence suporting its use in migraines. A blinded study comparing bisoprolol, 5 mg with metoprolol (Lopressor, Toprol), 100 mg, another beta blocker showed them to be equally effective in the treatment of migraines.
Will propranolol get rid of a migraine?
Based on studies that have been done to date, propranolol appears to be the most effective beta-blocker for treating and preventing migraine attacks. But, like most medications, beta-blockers can have side effects and can interact with other drugs.
Which is better for migraine propranolol or amitriptyline?
Amitriptyline significantly reduced the severity, frequency, and duration of headache attacks; propranolol reduced the severity of attacks only. Amitriptyline response was correlated with female gender and baseline headaches of shortest duration and of highest frequency.
What is the safest migraine prevention medicine?
Preventive drugs with the best proven efficacy for migraine are certain beta-blockers, divalproex sodium, and topiramate. The chosen drug should have the best risk-to-benefit ratio for the individual patient and, where possible, take advantage of the drug’s side effect profile.
Are triptans used for migraine prophylaxis?
Common side effects of triptans may include headache, dizziness, nausea, and fatigue, among other symptoms. When used for migraine prophylaxis, triptans can show effectiveness for migraine symptoms and prevention in a matter of hours.