Which blood cells are affected by dengue fever?
Dengue fever can result in a drop in your white blood cell and platelet counts. The normal platelet count in the body ranges from 1.5 to 4 lacs, this can go down to as low as 20,000 to 40,000 in the case of dengue patients.
How does dengue virus infect cells?
The dengue virus attaches to the surface of a host cell and enters the cell by a process called endocytosis. Once deep inside the cell, the virus fuses with the endosomal membrane and is released into the cytoplasm. The virus particle comes apart, releasing the viral genome.
How is dengue virus detected?
If an infection is suspected, you will get a blood test to check for the dengue virus. During a blood test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial.
How does dengue virus affect the body?
Dengue fever usually starts with a fever, joint pain, rash and nausea. Without treatment, the virus can cause damage to blood and lymph vessels and lead to dengue hemorrhagic fever, which is marked by difficulty breathing, bruising and bleeding from the nose, gums or under the skin.
Is WBC high in dengue?
Dengue fever is characterized by leucopenia (White Blood Cells (WBC) < 5000 cells/mm3), thrombocytopenia (< 150,000 cells/mm3), rising haematocrit (5–10%) and there should be no evidence of plasma leakage [10].
Why WBC is low in dengue?
This study may suggest that leukopenia in dengue fever may be caused by virus-induced destruction or inhibition of myeloid progenitor cells. Thrombocytopenia may result from by destruction of peripheral platelet or bone marrow megakaryocytes by viruses which consequently reduce the platelet production.
Does WBC count increase in dengue?
Why does WBC decrease in dengue?
How can a CBC detect dengue?
Here are the common tests recommended to diagnose dengue:
- Dengue NS1 Antigen. This is a blood test to detect the dengue virus early in the course of an infection.
- Immunoglobulin M (IgM)
- Immunoglobulin G (IgG)
- Dengue RNA PCR test.
How long do dengue antibodies last?
Serological methods. Serological methods, such as enzyme-linked immunosorbent assays (ELISA), may confirm the presence of a recent or past infection, with the detection of anti-dengue antibodies. IgM antibodies are detectable ~1 week after infection and remain detectable for about 3 months.
When does WBC increase in dengue?
Leukocytes reached nadir (1000-2000/mm3) at the 5th-6th day after fever onset, thrombocytes reached nadir (2.0-5.0 x 10(4)/mm3) at the 5th-7th day after fever onset.
What is the normal WBC level?
The normal number of WBCs in the blood is 4,500 to 11,000 WBCs per microliter (4.5 to 11.0 × 109/L). Normal value ranges may vary slightly among different labs. Some labs use different measurements or may test different specimens.