Where is platelet factor 3 found?
Tissue factor, also called platelet tissue factor, factor III, or CD142, is a protein encoded by the F3 gene, present in subendothelial tissue and leukocytes. Its role in the clotting process is the initiation of thrombin formation from the zymogen prothrombin.
What is the role of platelet factor 3?
Platelet factor 3 (PF3) is a platelet membrane component that plays an important role in the activation of the coagulation mechanism. Whenever platelet activation occurred, PF3 is released and participates in thrombin formation.
Does von Willebrand factor activate platelets?
Von Willebrand factor (VWF) is a large multimeric glycoprotein that performs two critical functions in primary hemostasis: it acts as a bridging molecule at sites of vascular injury for normal platelet adhesion, and under high shear conditions, it promotes platelet aggregation.
What does low antithrombin III mean?
The abnormal gene leads to a low level of the antithrombin III protein. This low level of antithrombin III can cause abnormal blood clots (thrombi) that can block blood flow and damage organs. People with this condition will often have a blood clot at a young age.
Where is Factor III produced?
Coagulation Factor III, also known as Tissue Factor (TF), Thromboplastin, and CD142, is the primary initiator of the extrinsic coagulation pathway. It is a transmembrane protein that is consitutively expressed in subendothelial cells throughout the vasculature and is inducible on endothelial cells and monocytes.
Is platelet factor 3 a phospholipid?
A phospholipid from the platelet membrane that contributes to the blood clotting cascade by forming a phospholipid-protein complex (THROMBOPLASTIN) which serves as a cofactor with FACTOR VIIA to activate FACTOR X in the extrinsic pathway of BLOOD COAGULATION. …
Is tissue factor factor 3?
Coagulation Factor III, also known as Tissue Factor (TF), Thromboplastin, and CD142, is the primary initiator of the extrinsic coagulation pathway. Coagulation Factor III plays an important role in thrombotic diseases, disseminated intravascular coagulation, and atherosclerosis.
Can von Willebrand disease cause low platelet count?
Affected individuals may develop classic bleeding symptoms including chronic nosebleeds and bleeding following surgery, dental procedures or trauma. Affected individuals may also experience a low platelet count (thrombocytopenia). Individuals with PT-VWD are difficult to distinguish from individuals VWD type 2B.
What is Factor 3 blood disorder?
It occurs when a person receives one abnormal copy of the antithrombin III gene from a parent with the disease. The abnormal gene leads to a low level of the antithrombin III protein. This low level of antithrombin III can cause abnormal blood clots (thrombi) that can block blood flow and damage organs.
What activates Factor VII?
Factor VII is feedback activated by many of the proteases produced during the blood coagulation response, but the extent of the thrombin production reaction is largely dependent on the preexistent concentration of factor VIIa in plasma and the concentration of tissue factor presented by the vascular lesion.