What type of cells are Reed-Sternberg cells?
Reed-Sternberg cells are large, abnormal lymphocytes (a type of white blood cell) that may contain more than one nucleus. These cells are found in people with Hodgkin lymphoma. Reed-Sternberg cells are also called Hodgkin and Reed-Sternberg cells.
How are Reed-Sternberg cells identified?
Reed–Sternberg cells (also known as lacunar histiocytes for certain types) are distinctive, giant cells found with light microscopy in biopsies from individuals with Hodgkin lymphoma. They are usually derived from B lymphocytes, classically considered crippled germinal center B cells.
What are the 4 types of Hodgkin’s lymphoma?
classical Hodgkin lymphoma includes four subtypes, all of which are treated in the same way:
- nodular sclerosis classical Hodgkin lymphoma.
- mixed cellularity classical Hodgkin lymphoma.
- lymphocyte-rich classical Hodgkin lymphoma.
- lymphocyte-depleted classical Hodgkin lymphoma.
What do Reed-Sternberg cells represent?
Reed-Sternberg cells are the hallmark tumor cells of Hodgkin lymphoma. They represent less than 1% of the tumor tissue, while the majority of cells in the tissue include T cells, B cells, eosinophils, macrophages, and plasma cells [11].
Are Reed-Sternberg cells B cells?
Reed-Sternberg (RS) Cells. Reed-Sternberg cells have been convincingly shown to be of B-cell lineage although they have an unusual and characteristic phenotype (CD30+, CD15+, fascin+, LCA-).
What are Reed-Sternberg cells derived from?
They build together with the mononucleated Hodgkin cells the tumor cell clone in Hodgkin lymphoma and derive from Hodgkin cells through incomplete cytokinesis. Reed–Sternberg cells originate from mature B cells, or in very rare instances from T cells.
What are Hodgkin and Reed-Sternberg cells?
Hodgkin and Reed/Sternberg (HRS) cells are the hallmark cells of Hodgkin’s lymphoma (HL). They are large, often multinucleated with a peculiar morphology and an unusual immunophenotype, that does not resemble any normal cell in the body.