What is the pathology of atherosclerosis?
Atherosclerosis is the pathologic process of lipid accumulation, scarring, and inflammation in the vascular wall, particularly the subendothelial (intimal) space of arteries, leading to vascular wall thickening, luminal stenosis, calcification, and in some cases thrombosis.
Is atherosclerosis a pathological disease?
Atherosclerosis has been a human disease for >3,500 years; it occurred in Egyptian mummies and showed the same pathologic features that are observed in modern times.
What is atherosclerosis write its etiology and pathophysiology?
Atherosclerosis is the buildup of fats, cholesterol and other substances in and on your artery walls. This buildup is called plaque. The plaque can cause your arteries to narrow, blocking blood flow. The plaque can also burst, leading to a blood clot.
What is the causes of atherosclerosis and arteriosclerosis?
Atherosclerosis happens when the endothelium becomes damaged, due to factors such as smoking, high blood pressure, or high levels of glucose, fat, and cholesterol in the blood. This damage allows a collection of substances, known as plaque, to build up in the artery wall. These substances include fat and cholesterol.
What is atherosclerosis give the etiology and pathogenesis of atherosclerosis?
Atherosclerosis is a multifocal, smoldering, immunoinflammatory disease of medium-sized and large arteries fuelled by lipids. Endothelial cells, leukocytes, and intimal smooth muscle cells are the major players in the development of this disease.
What is the first step in the pathophysiology of atherosclerosis?
The oxidation of low density lipoprotein (LDL) to Ox-LDL indicates the first step of atherosclerosis in cardiovascular diseases. Malondialdehyde factor shows the level of lipoperoxidation and is a sign of increased oxidative pressure and cardiovascular diseases.
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