What is Immunophenotype in leukemia?
The identification of leukemia-associated immunophenotypes can be used for monitoring minimal residual disease during therapy. The presence of cells expressing these phenotypes in patients who are in clinical remission is associated with an increased risk of relapse.
What is the meaning of Immunophenotype?
Listen to pronunciation. (IH-myoo-noh-FEE-noh-ty-ping) A process that uses antibodies to identify cells based on the types of antigens or markers on the surface of the cells. This process is used in basic research and to help diagnose diseases, such as specific types of leukemia and lymphoma.
How do you calculate Immunophenotype?
Immunophenotyping is a test in which the cells in a sample of blood or bone marrow are looked at under a microscope to find out if malignant lymphocytes (cancer) began from the B lymphocytes or the T lymphocytes. The process identifies cells based on the types of antigens or markers on the surface of the cell.
What is a immunophenotyping test?
With immunophenotyping, a blood, bone marrow, or other tissue sample can be tested to gather this information – information that is then used to identify a specific type of leukemia or lymphoma and, where possible, used to predict its likely aggressiveness and/or responsiveness to certain treatment.
What is cytometry testing?
Flow cytometry is a laser-based technique used to detect and analyze the chemical and physical characteristics of cells or particles. It is most commonly used to evaluate bone marrow, peripheral blood and other fluids in your body. Test Details.
Why do we do immunophenotyping?
Immunophenotyping is requested primarily to help diagnose and classify blood cell cancers (leukaemias and lymphomas).
What is the importance of immunophenotyping?
Immunophenotyping is a test used to identify cells on the basis of the types of markers or antigens present on the cell’s surface, nucleus, or cytoplasm. This technique helps identify the lineage of cells using antibodies that detect markers or antigens on the cells, hence the “immuno-” prefix.
Is immunophenotyping same as flow cytometry?
The most common use of flow cytometry is in the identification of markers on cells, particularly the immune system or immunophenotyping. It is the desire to detect an increased number of cell subsets of the immune system that has driven the increase in multicolor flow cytometry.
What are Monotypic B cells?
Any B-cell population or subset of B cells identified by heterogeneous antigen expression with a κ/λ ratio below 0.5 or above 5.0 was regarded as monotypic. The MBP cases were divided into three groups according to their phenotypes: CLL-like, CD5+ with phenotype not typical for CLL, and CD5−.
What is cytometry used for?
Flow cytometry is a laser-based technique used to detect and analyze the chemical and physical characteristics of cells or particles. It is most commonly used to evaluate bone marrow, peripheral blood and other fluids in your body.
How long does it take to get flow cytometry results?
Results are submitted for hematopathologist review and interpretation. The typical turn-around time for our diagnostic flow cytometry results is within 1-3 days.