What is G-CSF used for?
G-CSF is used in patients who have certain cancers and neutropenia caused by some types of chemotherapy and in patients who have severe chronic neutropenia that is not caused by cancer treatment. It is also used before an autologous stem cell transplant. G-CSF helps the bone marrow make more white blood cells.
Why is E coli G-CSF?
Filgrastim is a 175 amino acid protein, containing an extra N-terminal methionine, which is needed for expression in E. coli. Here we describe a simple and low-cost process that is amenable to scaling-up for the production and purification of homogeneous and active recombinant hG-CSF expressed in E.
What is the difference between G-CSF and GM CSF?
The G-CSF receptor (G-CSFR; CD114) is a homo-oligo-dimer, whereas the GM-CSF receptor (GM-CSFR; CD116) is a hetero-oligo-dimer sharing a β-chain with the IL-3 and IL-5 receptors. The G-CSFR is expressed primarily on neutrophils and bone marrow precursor cells.
How is G-CSF given?
Filgrastim may be given subcutaneous (the layer between the skin and muscle) injection or infused into a vein (intravenous, IV). Filgrastim is generally given on a daily basis. The number of days you receive filgrastim will be prescribed by your doctor.
What is hG CSF?
Human granulocyte colony-stimulating factor (hG-CSF) is a proliferation, differentiation, survival and activation factor for hematopoietic cells [1]. hG-CSF consists of various products, which are derived from different tissues. hG-CSF stimulates the bone marrow to produce granulocytes by releasing them into the blood.
When should G-CSF be administered?
G-CSF is usually started 24 hours or more after your chemotherapy finishes. You usually have it daily. Your doctor or pharmacist will tell you how many injections you need. Some types of G-CSF stay in the body for longer.
What is G-CSF in immunology?
Granulocyte colony-stimulating factor (G-CSF), also called colony-stimulating factor 3 (CSF3), is a primary cytokine that promotes the proliferation, differentiation and survival of neutrophil progenitors and enhances trafficking and immunological functions of mature neutrophils in mammals (1).