What is ERBB2 amplification?
ERBB2 Amplification is a predictive biomarker for use of trastuzumab, lapatinib, pertuzumab, ado-trastuzumab emtansine, aromatase inhibitor, fam-trastuzumab deruxtecan, capecitabine, endocrine therapy, cisplatin, docetaxel, paclitaxel, carboplatin, fluorouracil, margetuximab, neratinib, pembrolizumab, pertuzumab/ …
Is ERBB2 a tumor suppressor gene?
ErbB2-intronic MicroRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling | Cell Death & Disease.
What does amplification of HER2 mean?
HER2 proteins are receptors on breast cells. Normally, HER2 receptors help control how a healthy breast cell grows, divides, and repairs itself. But in about 10% to 20% of breast cancers, the HER2 gene doesn’t work correctly and makes too many copies of itself (known as HER2 gene amplification).
What is chromosomal amplification?
Gene amplification represents a situation where there is an increase in the amount of DNA present in a specific region of a chromosome. Chromosomal abnormalities observed in karyotype preparations such as homogeneously stained regions, abnormal banding patterns, and double minutes are the result of gene amplification.
What is ERBB2 gene?
The erbB2 (also known as HER2 or neu) gene encodes a 185-kDa transmembrane glycoprotein, which belongs to the epidermal growth factor receptor (EGFR) family. ErbB2 is a receptor tyrosine kinase with intrinsic tyrosine kinase activity.
What is the difference between ERBB2 and HER2?
The HER2 is the legacy gene symbol for ERBB2 and may be more commonly used by the community; HER2 is also commonly used to describe the protein encoded by the ERBB2 gene. One unique feature of HER2 compared with the other receptors in the HER family is the absence of a known ligand.
Is ERBB2 an RTK?
The ErbB receptor tyrosine kinase family (RTK class I) consists of four cell surface receptors: ErbB1/EGFR/HER1, and ErbB2-4/HER2-4[1]. ERbB receptor tyrosine kinases have important roles in human cancer.
What causes HER2 gene amplification?
This is caused by a mutation in the HER2 (human epidermal growth factor receptor 2) gene. When the HER2 gene mutates, it causes cells in the breast to grow and divide at an uncontrolled rate, leading to tumor growth.
When does gene amplification occur?
Is HER2 and ERBB2 the same?
What chromosome is ERBB2 on?
ERBB2 is a transmembrane tyrosine kinase receptor encoded by a gene located in chromosome region 17q12. Overexpression of ERBB2, generally by way of gene amplification, plays a role in mammary oncogenesis.