What is cartilage hypertrophy?
Chondrocyte hypertrophic differentiation is the gradual development process from chondrogenic differentiation to cartilage mineralization, which is characterized by a series of markers; each of these markers has its own function in the process of cartilage mineralization.
Does osteoarthritis cause hypertrophy?
Results: Chondrocyte hypertrophy-like changes are reported in both human OA and experimental OA models by most investigators. These changes play a crucial part in the OA disease process by protease-mediated cartilage degradation.
What is the difference between Osteocyte and chondrocyte?
Summary – Chondrocytes vs Osteocytes Osteocytes and chondrocytes are the cells of bone and cartilage, respectively. They originate from mesenchymal cells. Osteocytes are developed in the mucoid connective tissue and a mature osteocyte contains a single nucleus. Chondrocytes are involved in the maintenance of cartilage.
What is chondrocyte ossification?
During endochondral ossification, chondrocytes proliferate, undergo hypertrophy and die; the cartilage extracellular matrix they construct is then invaded by blood vessels, osteoclasts, bone marrow cells and osteoblasts, the last of which deposit bone on remnants of cartilage matrix.
Is Aggrecan a gag?
Almost 90% of aggrecan mass is comprised of substituted GAG chains which are mostly chondroitin sulfate chains, but also include keratan sulfate chains with N- and O-linked oligosaccharides.
What is a chondrocyte?
Chondrocytes are metabolically active cells that synthesize and turnover a large volume of extra cellular matrix (ECM) components such as collagen, glycoproteins, proteoglycans, and hyaluronan [2]. Chondrocytes are derived from MSCs and occupy only 1%–5% of the total cartilage tissue [7].
What happens when cartilage cells hypertrophy?
Chondrocytes that undergo hypertrophy-like changes produce a number of proteins that are involved in tissue remodeling and calcification. A number of (transcription) factors regulate the differentiation from a normal articular chondrocyte to a terminal differentiated chondrocyte.
What happens to hypertrophic chondrocytes?
We show that hypertrophic chondrocytes can survive the cartilage-to-bone transition and become osteoblasts and osteocytes during endochondral bone formation and in bone repair.