What is carbapenem-resistant Pseudomonas?
Carbapenems are a class of antibiotics that were developed to treat bacteria that are resistant to other drugs. Because of the overuse of these antibiotics, some types of Pseudomonas have developed resistance to carbapenems, and these bacteria are called carbapenem-resistant Pseudomonas aeruginosa (CRPA).
Why is Pseudomonas aeruginosa important?
Pseudomonas aeruginosa has become an important cause of gram-negative infection, especially in patients with compromised host defense mechanisms. It is the most common pathogen isolated from patients who have been hospitalized longer than 1 week, and it is a frequent cause of nosocomial infections.
Who discovered Pseudomonas aeruginosa?
In 1882 Carle Gessard, a chemist and bacteriologist from Paris, France, discovered P. aeruginosa through an experiment that identified this microbe by its water-soluble pigments that turned a blue-green when exposed to ultra-violet light.
Which antibiotics is Pseudomonas resistant to?
Pseudomonas isolates were most highly resistant to imipenem (95.3%), followed by trimethoprim-sulfamethoxazole (69.8%), aztreonam (60.5%), chloramphenicol (45.3%), and meropenem (27.9%). Their multiple antibiotic resistance (MAR) index values ranged from 0.0 to 0.8.
What is carbapenem-resistant Klebsiella pneumoniae?
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is one of the carbapenem-resistant Enterobacteriaceae (CRE), an emerging cause of antibiotic-resistant, health care-associated infections. CRE were listed as one of the most urgent antibiotic resistance threats by the CDC and WHO (4, 5).
Is Pseudomonas prokaryotic or eukaryotic?
A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence.
What are the characteristics of Pseudomonas?
Characteristics
- Rod-shaped.
- Gram-negative.
- Flagellum one or more, providing motility.
- Aerobic.
- Non-spore forming.
- Catalase-positive.
- Oxidase-positive.
Does Pseudomonas aeruginosa grow on MacConkey Agar?
Apart from the media mentioned above, Pseudomonas aeruginosa can also be grown in MacConkey agar (a bacterial culture medium commonly used to grow lactose fermenting bacteria). In MacConkey agar, Pseudomonas aeruginosa forms flat and smooth colonies that are between 2 and 3mm in diameter.
What is resistant Pseudomonas?
Pseudomonas aeruginosa, a leading nosocomial pathogen, may become multidrug resistant (MDR). Its rate of occurrence, the individual risk factors among affected patients, and the clinical impact of infection are undetermined.
What are four different mechanisms that Pseudomonas can use to become more resistant to an antibiotic?
Pseudomonas aeruginosa expresses twelve RND family efflux pumps, four of which (MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY-OprM) contribute to antibiotic resistance (Dreier and Ruggerone, 2015).