What is Axitinib target?
Axitinib prevents the progression of cancer by inhibiting angiogenesis and blocking tumor growth. Axitinib selectively blocks the tyrosine kinase receptors VEGFR-1 (vascular endothelial growth factor receptor), VEGFR-2, and VEGFR-3.
Is axitinib a tki?
Axitinib is a tyrosine kinase inhibitor (TKI) which is a cancer growth blocker. Tyrosine kinase inhibitors work by blocking certain proteins called tyrosine kinases from acting on cells. Tyrosine kinases signal to cancer cells to grow.
How do you dissolve axitinib?
A stock solution may be made by dissolving the axitinib in the solvent of choice, which should be purged with an inert gas. Axitinib is soluble in organic solvents such as DMSO and dimethyl formamide. The solubility of axitinib in these solvents is approximately 2.5 and 0.25 mg/ml, respectively.
What is the half life of axitinib?
Axitinib has a short effective plasma half-life (range 2.5-6.1 h), and the plasma accumulation of axitinib is in agreement with what is expected based on the plasma half-life of the drug.
Is axitinib an immunotherapy?
Immunotherapy with monoclonal antibodies, such as avelumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Talazoparib and axitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Is axitinib a chemo drug?
Axitinib (Inlyta®) is a Chemotherapy Regimen for Renal Cell Carcinoma – Kidney Cancer.
Is axitinib a chemotherapy drug?
How is axitinib given?
Axitinib comes as a tablet to take by mouth. It is usually taken with or without food two times a day. Take axitinib at around the same times every day, about 12 hours apart. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
What are the side effects of axitinib?
Axitinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- diarrhea.
- decrease in appetite or ability to taste things.
- weight loss.
- nausea.
- vomiting.
- constipation.
- tiredness.
- weakness.
What is the molecular weight of axitinib?
Molecular Weight(MW): 386.47. Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.
What is axitinib (AG 013736)?
Axitinib (AG 013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.
What is the target of axitinib?
Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively. Features.
Is Axitinib a VEGFR inhibitor?
Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.