What is an H2B mouse?
H2B Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
What is a GFP mouse?
UBC-GFP transgenic mice express green fluorescent protein directed by the human ubiqutin C promoter, and were discovered to have transgene insertion on chromosome 17 resulting in linkage to H-2b MHC haplotype (see details below). This transgene is also available on BALB/CBy as Stock No.
What is H2B GFP?
The H2B–GFP system allows chromosomes, including DMs, to be imaged at a high resolution without perturbing cell cycle control or intracellular structures. The application of this system has revealed the distinctive clustering behavior of DMs in living mitotic cells.
What is H2B mCherry?
Maize histone H2B-mCherry: a new fluorescent chromatin marker for somatic and meiotic chromosome research. DNA Cell Biol.
What is MIP GFP mice?
These “MIP-GFP” transgenic mice express Enhanced Green Fluorescent Protein (EGFP) under the control of the mouse insulin 1 promoter. This mutant mouse strain may be useful in studies of diabetes and pancreatic beta islet cell biology.
What is H2B tag?
What does Hoxc13 make fluorescent in mice?
Keywords: gene targeting/Hoxa1/Hoxc13. The jellyfish, Aequorea victoria, produces a protein, green fluorescent protein (GFP), which absorbs blue light and emits green light.
Who created the glowing mice?
To better investigate mitochondrial function, a team of researchers from Switzerland’s Ecole Polytechnique Fédérale de Lausanne developed a method to make mice glow in the dark, like fireflies. Their work was published today in the journal Nature Chemical Biology.
Do humans have the GFP gene?
In cell and molecular biology, the GFP gene is frequently used as a reporter of expression. To date, GFP has been expressed in many species, including bacteria, yeasts, fungi, fish and mammals, including in human cells.
How are fluorescent mice made?
A technique which enables the earliest stages of cancer to be observed in living mice has been developed. To do this they genetically-engineered mice by adding a fluorescent gene from fireflies to them. In this case the fluorescence gene is switched on when the normal p16 gene is activated.