What is a subtherapeutic INR?
A subtherapeutic INR could be caused by a change in general medical condition. This can cause problems when a patient is acutely unwell, thus, close monitoring of INR may be necessary. Disease states that are known to decrease INR include hypothyroidism, diabetes mellitus, oedema, hyperlipidaemia and visceral carcinoma.
What is heparin INR?
In absolute terms, the INR increased from a baseline of 1.87 at 0 U/mL of heparin to 2.88 at 0.9 U/mL.
What is international normalized ratio INR?
The international normalized ratio (INR) is a calculation based on results of a PT and is used to monitor individuals who are being treated with the blood-thinning medication (anticoagulant) warfarin (Coumadin®). The PT and INR are used to monitor the effectiveness of the anticoagulant warfarin.
What is subtherapeutic level?
Definition of subtherapeutic : less than therapeutic : having, using, or being a dose that is below what is used for treating disease or producing an optimal therapeutic effect … with a fixed dose of 95 mg/kg/day, initial levels during the febrile phase were subtherapeutic (<20 mg/dL)…— Gideon Koren et al.
What is the risk of having a subtherapeutic INR?
Conclusion: Patients with stable INRs while receiving warfarin who experience a significant subtherapeutic INR value have a low risk of thromboembolism in the ensuing 90 days. The risk was similar to that observed in a matched control population in whom therapeutic anticoagulation was maintained.
Is INR 1.12 normal?
The normal range for a healthy person not using vitamin K antagonists is 0.8–1.2, while on oral anticoagulant therapy the accepted target usually is in the range of 2.0–3.0. A high INR indicates a higher risk of bleeding, while a lower INR suggests a higher risk of thrombosis.
What is PT INR and aPTT?
Types of Test Two of the tests used in a coagulation study—prothrombin time (PT) and partial thromboplastin time (PTT, also known as aPTT)—can reveal specific things about your health. The third, called the international normalized ratio (INR), is technically a calculation more than it is a test.
What is high INR mean?
When the INR is higher than the recommended range, it means that your blood clots more slowly than desired, and a lower INR means your blood clots more quickly than desired.
What causes INR to rise?
The result of the test is called the INR level. A high INR level can happen when you take warfarin (Coumadin). Warfarin helps prevent blood clots. To do this, it slows the amount of time it takes for your blood to clot.
What is subtherapeutic effect?
(ˌsʌbθɛrəˈpjuːtɪk) adjective pharmacology. involving or relating to drug dosages administered at too low a level to produce a therapeutic effect. (of a drug dosage) below the level necessary to treat disease, not powerful enough to have a therapeutic effect.