What is a reptilase test?
Reptilase time (RT) test is used to evaluate a prolonged TT. Reptilase is a thrombin-like enzyme isolated from the venom of Bothrops atrox. Thrombin splits small fibrinopeptides A and B from fibrinogen molecules, producing fibrin monomer, which polymerizes to form a clot.
What is the function of reptilase in coagulation testing?
The reptilase time measures the rate of fibrin clot formation after the addition of reptilase, a proteolytic enzyme derived from the venom of Bothrops atrox, to citrated plasma.
What is reptilase time used for?
Reptilase time is a specific coagulation test designed to assess fibrin formation from fibrinogen in plasma. Reptilase time is modified TT when thrombin is replaced with enzyme “reptilase” purified from snake venom.
Which of the following is used to confirm or exclude the presence of heparin in the specimen?
As the commonest cause of prolongation of both PT and APTT is heparin, the thrombin time is performed as a quick test to exclude this possibility. If heparin (or heparin like sub- stances and other thrombin inhibitors) is the cause of the prolonged thrombin time, the normal reptilase time will confirm this.
What is dRVVT blood test?
Dilute Russell’s viper venom time (dRVVT) is a laboratory test often used for detection of lupus anticoagulant (LA).
What does dysfibrinogenemia mean?
Dysfibrinogenemia is a coagulation (clotting) disorder characterized by having an abnormal form of fibrinogen.[11855] Fibrinogen is a protein produced by the liver which helps control bleeding by helping blood clots to form.[11856] Having abnormal fibrinogen results in defective clot formation and can cause an …
What is Echis time?
Ecarin clotting time (ECT) is a laboratory test used to monitor anticoagulation during treatment with hirudin, an anticoagulant medication which was originally isolated from leech saliva. Ecarin, the primary reagent in this assay, is derived from the venom of the saw-scaled viper, Echis carinatus.
What is fibrinogen?
A protein involved in forming blood clots in the body. It is made in the liver and forms fibrin. Fibrin is the main protein in a blood clot that helps stop bleeding and heal wounds.
Why EDTA is not used for coagulation?
EDTA is not recommended for coagulation studies .. because, there is rapid lost of 2 factors which is very important in coagulation mechanism (VIII and V) called labile factor another matter the calcium would precipitated.
What does DRVVT positive mean?
If your test results are positive, your healthcare provider is likely to order other special blood-clotting tests. They might include: Activated partial thromboplastin time. Anticardiolipin antibody. Modified Russell viper venom time, or MRVVT.
What is normal range for DRVVT screen?
Provides information to assist in interpretation of the test results. Dilute Russell viper venom time (DRVVT) screen ratio (<1.20): A normal DRVVT screen ratio (<1.20) indicates that lupus anticoagulant (LA) is not present or not detectable by this method (but might be detected with other methods).