What is 2-deoxyglucose used for?
Therapeutically, 2-deoxyglucose is an investigational drug that is being studied as an anticancer and antiviral agent. Concerning the former, 2- deoxyglucose was used as an adjunct to chemotherapy and radiotherapy in the treatment of solid tumors (lung, breast, pancreas, head, neck, and gastric tumors).
How does 2-deoxyglucose affect glycolysis?
Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-d-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6-phosphate isomerase, and inducing cell death.
How do you make 2 deoxy D-glucose?
The preparation method comprises the following steps: taking 3,4,5-tri-O-acetyl D-glucal or 3,4,5-tri-hydroxy-glucal as a raw material, and is placed in a solvent under existence of solid acid, stirring and reacting for certain time under certain temperature, filtering to remove solid acid, washing the solid acid by …
Is 2-deoxyglucose a competitive inhibitor?
Although metrizamide, 2-deoxyglucose, and glucosamine are known to be competitive inhibitors of approximately equal potency for glucose of yeast hexokinase (Ki approximately 0.7 mM for all three), metrizamide is a much weaker competitive inhibitor (Ki about 20 mM) of rat brain hexokinase than either 2-deoxyglucose or …
Is D 2 Deoxygalactose the same chemical as d2 deoxyglucose?
Is D-2-deoxygalactose the same chemical as D-2-deoxyglucose? Explain. Both cellulose and glycogen are polymers of D-glucose but they differ in their glycosidic linkage. You just studied 11 terms!
What type of molecule is hexokinase?
Abstract. Hexokinases are intracellular enzymes that phosphorylate glucose, mannose and fructose to the corresponding hexose 6-phosphates. The resulting phosphate esters can then be broken down to pyruvate by glycolysis or used for different biosynthesis. Hexokinases play an important role in the control of glycolysis.
What does 2 deoxyglucose do to ATP?
Inhibition of this rate-limiting step by 2-DG depletes the cellular ATP, leading to blockage of cell cycle progression and cell death in vitro28. Our results showed that 2-DG could decrease the glycolysis level in polycystic kidney epithelial cells.
What type of enzyme is Phosphoglucoisomerase?
Phosphoglucoisomerase (alternatively known as phosphoglucose isomerase or Glucose-6-phosphate isomerase) are a group of enzymes of the isomerase family (EC 5.3. 1.9), so named for their main function in glycolysis and gluconeogenesis.
Is 2-DG trapped in the cell?
2DG enters the cell through the glucose transporter and is phosphorylated by hexokinase. Due to low levels of intracellular phosphatase, 2-DG-PO4 is trapped in the cell.
Is D 2 deoxyglucose the same chemical as D 2 deoxyglucose provide a short and unique explanation?
These two molecules are not the same because they differ in configuration at C−2 atoms.
What is the difference between Hemiacetal and glycoside?
Hemiacetal is made by addition of an alcohol to an aldose or ketose. And glycoside is made by condensing hemiacetal with an alcohol.