What does it mean to have 48 chromosomes?
48,XXXY syndrome is a sex chromosome disorder in boys and men that results from having two extra X chromosomes in each cell. People typically have 46 chromosomes in each cell, two of which are the sex chromosomes. Females have two X chromosomes (46,XX), and males have one X chromosome and one Y chromosome (46,XY).
How many Barr bodies are present in XXYY?
For example, people with Klinefelter syndrome (47, XXY) have a single Barr body, and people with a 47, XXX karyotype have two Barr bodies.
What is XXYY?
XXYY syndrome. XXYY syndrome is a sex chromosome anomaly in which males have an extra X and Y chromosome. Human cells usually contain two sex chromosomes, one from the mother and one from the father. Usually, females have two X chromosomes (XX) and males have one X and one Y chromosome (XY).
Is there XXYY?
The occurrence of 48, XXYY is 1 in 17,000 live male births. The occurrence of Klinefelter Syndrome, XXY, is 1 in 500.
Do humans have 46 or 48 chromosomes?
In humans, each cell normally contains 23 pairs of chromosomes, for a total of 46. Twenty-two of these pairs, called autosomes, look the same in both males and females. The 23rd pair, the sex chromosomes, differ between males and females.
What is Barr body in genetics?
Definition of Barr body : a densely staining inactivated condensed X chromosome that is present in each somatic cell of most female mammals and is used as a test of genetic femaleness (as in a fetus) — called also sex chromatin.
How many Barr bodies would a male with XXYY chromosomes have in each of his cells select the correct answer?
These masses are called Barr bodies after the cytologist who discovered them. XX females have one Barr body per cell, XXX females have 2 Barr bodies per cell, and XXY Klinefelter males have one Barr body per cell (Barr bodies are not observed in XY males).
Do all primates have 48 chromosomes?
Based on fossil evidence and comparative anatomy, Charles Darwin proposed that humans and great apes–which include chimpanzees, gorillas, and orangutans–share a common ancestor that lived several million years ago. While great apes all have 48 chromosomes (24 pairs), humans have only 46 (23 pairs).
What is 48 XYYY syndrome?
Disease definition. 48,XYYY syndrome is a rare Y chromosome number anomaly that affects only males and is characterized by mild-moderate developmental delay (especially speech), normal to mild intellectual disability, large, irregular teeth with poor enamel, tall stature and acne.
What are the physical findings characteristic of 48-xxxy syndrome?
Other physical differences associated with 48,XXXY syndrome include abnormal fusion of certain bones in the forearm (radioulnar synostosis), an unusually large range of joint movement ( hyperextensibility ), elbow abnormalities, curved pinky fingers (fifth finger clinodactyly ), and flat feet ( pes planus ).
How many chromosomes do you have with 48 XXXY syndrome?
Boys and men with 48,XXXY syndrome have the usual single Y chromosome, but they have three copies of the X chromosome, for a total of 48 chromosomes in each cell. Boys and men with 48,XXXY syndrome have extra copies of multiple genes on the X chromosome.
What is the prevalence of karyotype 47 XXY?
Not surprisingly, less than 10% of cases are recognized before puberty. The classic 47,XXY karyotype is the result of meiotic non-disjunction during gametogenesis, of which 60% occur during oogenesis. About 10% of cases are mosaic (46,XY/47,XXY) and tend to have a milder phenotype.