What does homozygous MTHFR A1298C mean?
Being homozygous for MTHFR A1298C leads to 60% of normal enzyme function. People may also have 1 abnormal MTHFR C677T gene plus 1 abnormal MTHFR A1298C gene; this is termed double heterozygous. Decreased enzyme function may also result.
How is MTHFR homozygous treated?
Natural treatments for MTHFR mutation symptoms
- Consume more folate and vitamin B12. Consuming more folate in your diet may aid with methylation.
- Support detoxification.
- Minimize alcohol intake.
- Manage your stress with lifestyle changes.
- Check your supplements.
- Heal any underlying digestive issues.
How is MTHFR mutation treated?
MTHFR mutations do not require medical treatment. That said, making dietary and lifestyle changes can often help offset any resulting nutritional deficiencies. For example, people with high homocysteine levels due to folate or vitamin B12 deficiencies can take folic acid or vitamin B12, respectively.
What is A1298C heterozygous mutation?
The A1298C mutation, like the C677T mutation, results in a decrease in MTHFR activity that is more pronounced in the homozygous (CC) than in the heterozygous (AC) or normal (AA) states, and does not result in a thermolabile protein.
What is homozygous condition?
Homozygous Homozygous is a genetic condition where an individual inherits the same alleles for a particular gene from both parents.
Is 5-MTHF methylated?
5-MTHF plays an essential role in methylation, it enables the conversion of homocysteine to methionine, the production of serotonin and melatonin, and it is indirectly involved in the synthesis of DNA.
Is L-methylfolate the same as 5-MTHF?
Methylfolate is known by various names: Methylfolate, 5-MHTF, and MTHF. And it comes in two isomers, the “L” or “6S” isomer is the active form, and it is also known as Levomefolate, L-5-MTHF, L-methylfolate and L-5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF.
What is a homozygous mutation?
It’s often used in the context of disease. We talk about a situation where an individual has inherited a mutant allele or an error in DNA sequence from their mother and they have inherited the identical mutant allele from their father. We would then say that individual is homozygous for that mutation.