What does CGD stand for?
» CGD stands for Chronic Granulomatous Disorder. It is a life-threatening and life-limiting condition. » CGD is an inherited genetic disorder.
Who gets CGD?
CGD is not common. Doctors diagnose it in about 1 out of every 200,000 to 250,000 people worldwide. CGD occurs more often in males than in females.
How is CGD treated?
A medicine called interferon-gamma may also help reduce the number of severe infections. Surgery may be needed to treat some abscesses. The only cure for CGD is a bone marrow or stem cell transplant.
What cells are affected by CGD?
Chronic granulomatous disease is a genetic disease. In CGD, mutations in any one of five different genes can cause a defect in an enzyme called phagocyte NADPH oxidase. Certain white blood cells use this enzyme to produce hydrogen peroxide, which these cells need in order to kill certain bacteria and fungi.
What is actimmune?
This medication is used to reduce the frequency and severity of serious infections due to chronic granulomatous disease, a disorder that runs in families. This drug is often used along with antibiotics to help prevent these serious infections.
What is CGD pathology?
CGD is an inherited disorder of phagocytic cells in which those cells are unable to kill bacteria and fungi because of a gene defect which does not allow the necessary respiratory burst. For this reason, the patient is subject to recurrent chronic infections. Most patients present during the first five years of life.
How do you get CGD?
Autosomal recessive CGD occurs when both parents pass on a faulty gene to their child. In autosomal recessive, both parents are carriers of CGD. They have 1 normal copy of the gene and 1 copy of the gene that doesn’t work right. But the most common way CGD is inherited is X-linked.
What happens in CGD?
Chronic granulomatous (gran-u-LOM-uh-tus) disease (CGD) is an inherited disorder that occurs when a type of white blood cell (phagocyte) that usually helps your body fight infections doesn’t work properly. As a result, the phagocytes can’t protect your body from bacterial and fungal infections.
Do granulomas show on CT scan?
When granulomas first form, they’re soft. Over time, they can harden and become calcified. This means calcium is forming deposits in the granulomas. The calcium deposits make these kinds of lung granulomas more easily seen on imaging tests, such as chest X-rays or CT scans.
What doctor treats chronic granulomatous disease?
Chronic granulomatous disease (CGD) specialists, usually immunologists, infectious disease physicians, hematologists, and oncologists, have expertise in treating CGD.
How is CGD diagnosed?
Your doctor may order several tests to diagnose CGD , including: Neutrophil function tests. Your doctor may conduct a dihydrorhodamine 123 (DHR) test or other tests to see how well a type of white blood cell (neutrophil) in your blood is functioning. Doctors usually use this test to diagnose CGD .
What causes CGD?
Causes. CGD is caused by defects in an enzyme, NADPH oxidase, that phagocytes need to kill certain bacteria and fungi. Mutations in one of five different genes can cause these defects.