What does CD10 stain for?
Conclusion: CD10 is a reliable and sensitive immunohistochemical marker of normal endometrial stroma. Positivity, which is often strong and/or diffuse is found in endometrial stromal nodules and low-grade ESS.
What is PAX8 positive?
PAX8-positive, calretinin-negative staining appears to be highly specific and sensitive for detecting metastatic ovarian serous carcinoma in cytological preparations and may prove useful for distinguishing these cells from mesothelial cells in fluid cytology (32).
What is CK19 positive?
CK19 is positive in the most of neuroendocrine tumors occurring in the rest of the GIT, except rectal tumors, which are negative. In the liver, CK19 is of prognostic value in hepatocellular carcinomas and is of use in distinguishing cholangiocarcinoma from hepatocellular carcinomas.
What cells are CD10-positive?
Among hematopoietic cells, CD10 expression is found in granulocytes and in B and T lymphocytes at particular stages of maturation. CD10 expression within the B-cell lineage has been very well characterized. Benign CD10+ B cells include B lymphoblasts as well as mature germinal center B cells (1, 18).
What is CD10-positive B-cell lymphoma?
Classic examples of CD5+/CD10+ B-cell lymphomas expressing are follicular lymphoma and Burkitt lymphoma. Hairy cell leukemia and mantle cell lymphoma can occasionally be positive for CD10. Some forms of DLBCL can also be CD10-positive.
What tumors are positive for PAX8?
These results show that PAX8 is a highly sensitive marker for thyroid, renal, Müllerian, and thymic tumors. Importantly, all lung adenocarcinomas, breast and adrenal neoplasms, and the majority of gastrointestinal tumors were negative for PAX8. Therefore, PAX8 is an excellent marker for confirming primary tumor site.
What is vimentin positive?
Mesenchymal and endothelial cells usually stain vimentin positive and thus act as a measure of internal quality control in immunoreactivity. Absence of immunostaining in these areas often indicates that there is significant damage to tissue antigens and loss of structural architecture.
What is CD10-positive B-cell lymphoproliferative disorder?
Can CD10 be used as a diagnostic tool in hepatocellular carcinoma?
Diagnostic utility of CD10 in differentiating hepatocellular carcinoma from metastatic carcinoma in fine-needle aspiration biopsy (FNAB) of the liver Diagn Cytopathol. 2004 Feb;30(2):92-7.doi: 10.1002/dc.10419.
Is vimentin a marker for sarcoma?
Vimentin is a nonspecific marker; however, a vimentin-negative tumour is unlikely to be a sarcoma (with the exception of alveolar soft part sarcoma), lymphoma, or melanoma [7].
What are the effects of CD10 methylation on epithelial cells?
In epithelial cells, CD10 loss from methylation leads to increased cell migration, cell growth and cell survival, contributing to neoplastic development and progression (J Pediatr Hematol Oncol 2010;32:2)
What are the markers for hepatocellular carcinoma (HCC)?
Finally, useful markers in favour of a hepatocellular carcinoma (HCC) are HepPar-1 and the canalicular markers CD10 or polyclonal CEA. They are expressed in the majority of HCCs (>80%) but sometimes in a heterogeneous way and mostly in well and moderately differentiated HCCs [64].