What are multilamellar vesicles used for?
Small multilamellar vesicles may have benefits over unilamellar vesicles for drug delivery, such as an increased volume for hydrophobic drugs. In addition, their altered mechanical properties might be beneficial for cellular uptake.
What drugs use liposomes?
Doxorubicin (Doxil) and Daunorubicin (anticancer drugs) may be given via liposomes. Liposomes is used in cancer therapy, since cancer cells have overexpressed folate and transferrin receptors, making transferrin and folic acid as suitable ligands [32].
What is multilamellar vesicle?
In multilamellar liposomes, vesicles have an onion structure. Classically, several unilamellar vesicles will form on the inside of the other with smaller size, making a multilamellar structure of concentric phospholipid spheres separated by layers of water [17].
What are the clinical application of a liposomal drug delivery system give example of drugs?
These delivery systems are used in diverse medical fields, including anti-cancer, anti-fungal and anti-inflammatory drugs as well as therapeutic gene delivery. Many clinical products, e.g., DoxilTM, AmBisome® and DepoDur [32] have been formulated using liposomes for clinical applications.
How are liposomes used in medical therapies?
Liposomes have been used to deliver anticancer agents in order to reduce the toxic effects of the drugs when given alone or to increase the circulation time and effectiveness of the drugs. DNA vaccination and improved efficiency of gene therapy are just a few of the upcoming applications of liposomes.
How do you make multilamellar vesicles?
Preparation of Multilamellar Vesicles (MLVs)
- Dissolve the lipids in chloroform.
- Combine the lipids in the appropriate ratio.
- Carefully evaporate the organic solvent using a dry nitrogen stream.
- Resuspend the lipid mixture in cyclohexane.
- Freeze the cyclohexane solution using dry ice.
How do liposomes release drugs?
A liposome has an aqueous solution core surrounded by a hydrophobic membrane, in the form of a lipid bilayer; hydrophilic solutes dissolved in the core cannot readily pass through the bilayer. These liposomes work to deliver drug by diffusion rather than by direct cell fusion.