What are mitral and tufted cells?
Mitral and tufted (M/T) cells are the projection neurons in the olfactory bulb; they send axons through the lateral olfactory tract onto several structures of the olfactory cortex. M/T axons are known to wait in the LOT (for about 2 days in the mouse) before sending collateral branches to the olfactory cortex.
What is the role of mitral and granule cells in the olfactory bulb?
Tufted cells and mitral cells receive the olfactory sensory inputs in the glomerulus and first process the odor signals in the local circuits within the glomerulus. The projection neurons further process the odor signals in the local circuits of the EPL and finally send the sensory information to the olfactory cortex.
Are mitral cells interneurons?
interneurons, known in vertebrates as mitral cells, that pass information to other parts of the brain.
What is the function of the olfactory bulb?
There are two olfactory bulbs on the bottom side of the brain, one above each nasal cavity. The olfactory bulbs receive information about smells from the nose and send it to the brain by way of the olfactory tracts.
How many mitral cells are in the glomerulus?
635 mitral cells
The full model was composed of 635 mitral cells (MCs) (5 for each glomerulus) and a total number of 97,017 granule cells (GCs), which uniformly filled the glomerular cell layer of our model (Migliore et al., 2014).
What do mitral cells innervate?
The mitral cell is the primary output neuron and central relay in the olfactory bulb of vertebrates. Further, this study shows that the majority of zebrafish mitral cells likely innervate a single glomerulus rather than multiple glomeruli.
What do granule cells do?
Granule cells are the smallest and most numerous type of neurons in the brain. They are involved in functions ranging from processing visual and motor information to learning and memory.
Where are pyramidal cells?
cerebral cortex
A common class of neuron found in the cerebral cortex of virtually every mammal, as well as in birds, fish and reptiles. Pyramidal neurons are also common in subcortical structures such as the hippocampus and the amygdala.
What is a mitral cell?
a cell in the olfactory bulb that carries olfactory information from the olfactory bulb to the rest of the brain (e.g. olfactory cortex) for processing.
What nerve controls sense of smell?
Olfactory nerve
Olfactory nerve (CN I) The olfactory nerve is a solely sensory nerve and conveys the sense of smell. Its receptors are located in the olfactory mucosa under the roof of the nasal cavity.
Do mitral cells regenerate?
Considering that mitral cells do not regenerate unlike OSNs, it may be unique characteristics of mitral cells to maintain the glomerular structure throughout the lifetime.