Is phenoxyethanol soluble in water?
Chemistry. Phenoxyethanol is an organic compound that has a water solubility of 27 g/L at 20°C.
What is 2-phenoxyethanol used for?
It is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative. It is also used as a fixative for perfumes, an insect repellent, a topical antiseptic, a solvent for cellulose acetate, some dyes, inks, and resins, in preservatives, pharmaceuticals, and in organic synthesis.
Is it safe to take 2-phenoxyethanol?
Phenoxyethanol is generally recognized as a safe, well-tolerated preservative. Yet, there have been a few reports of this substance causing adverse effects. In a 2010 case study, a woman developed an allergic reaction—in the form of hives and anaphylaxis—after using a skin care product with phenoxyethanol.
Is 2-phenoxyethanol the same as phenoxyethanol?
Phenoxyethanol (CAS n. 122-99-6) is an ether and aromatic alcohol, which is also known as 2-phenoxyethanol, ethylene glycol monophenyl ether, phenoxytol, 1-hydroxy-2-phenoxyethane and (2-hydroxyethoxy) benzene.
Why is 2-phenoxyethanol in vaccines?
2-Phenoxyethanol (2-PE) is a preservative in some vaccines and is effective against a broad spectrum of microorganisms but particularly against Pseudomonas aeruginosa. The action of 2-PE on gram-negative bacteria is reported to involve the disruption of cell membranes and the uncoupling of oxidative phosphorylation.
What is 2-phenoxyethanol in vaccines?
2-Phenoxyethanol is an organic chemical compound that is sometimes used in cosmetics and antiseptics. It is also currently used as a preservative in one FDA-approved available vaccine, Ipol, for the prevention of polio, at a concentration of 0.5%. Benzethonium chloride is a chemical that has antimicrobial properties.
How much phenoxyethanol is safe?
Yes, phenoxyethanol is safe. According to the Cosmetic Ingredient Review, when used in concentrations of 1% or less, phenoxyethanol in skin care is safe. This is also the same standard the European Commission on Health and Food Safety uses as well.
Is phenoxyethanol safe in vaccines?
Some vaccines do still use preservative ingredients to stay safe. The most common ingredient is thimerosal, occasionally phenol, 2-phenoxyethanol, and benzethonium chloride are used as preservative agents in vaccines (1).
What are the side effects of phenoxyethanol?
If you’re allergic to phenoxyethanol, you may develop a rash like hives on your skin where the product was applied. In severe cases, you may experience anaphylaxis. One study showed that parabens may enhance the effects of phenoxyethanol, leading to a stronger reaction. It may irritate eczema.
Why is 2-phenoxyethanol used in vaccines?
Also, the results of the safety test showed no necrotic skin lesions at the concentration of 0.5%. 2-Phenoxyethanol provides superior antimicrobial effectiveness over Thimerosal for vaccine formulation (Khandke et al., 2011. Where, it is suitable for use as a preservative vaccine (Eiji et al., 2002).
Should I avoid products with phenoxyethanol?
One study showed that parabens may enhance the effects of phenoxyethanol, leading to a stronger reaction. It may irritate eczema. If your skin is already sensitive because of eczema, avoid products with higher concentrations of phenoxyethanol. If you do have a reaction, discontinue use.