Is alpha-ketoglutarate toxic?
Oral treatment of alpha-ketoglutarate (A-KG) is known to antagonise experimental cyanide poisoning in rodents. Maximum protective efficacy of A-KG has been observed at a dose of 2.0 g kg-1 body weight but no acute toxicity has been observed at this dose level.
Where is alpha-ketoglutarate found in the cell?
Because AKG is a key intermediate in the Krebs cycle, it is mainly found in cells (in mitochondria and cytoplasm), but it can also be detected in small quantities (µM) in the bloodstream (Martin et al.
Is alpha-ketoglutarate healthy?
Alpha-ketoglutaric acid is a biological compound found naturally in the human body. It plays a key role in the Krebs cycle—a series of chemical reactions used to release stored energy. Alpha-ketoglutaric acid is said to offer a variety of health benefits, including enhanced athletic performance and improved metabolism.
Is alpha-ketoglutarate an intermediate?
Alpha-ketoglutarate (AKG), also referred to as 2-ketoglutaric acid, 2-oxoglutamate, 2-oxoglutaric acid, oxoglutaric acid and 2-oxopentanedioic acid (Harrison and Pierzynowski, 2008), is a rate-determining intermediate in the tricarboxylic acid (TCA) and has a crucial role in cellular energy metabolism.
Is alpha-ketoglutarate stable?
a-ketoglutarate is a stable chemical. It is safe to store at 2-8 deg temperature.
What is alpha-ketoglutarate converted to?
Alpha-ketoglutarate dehydrogenase (α-KGDH) is a highly regulated enzyme, which could determine the metabolic flux through the Krebs cycle. It catalyses the conversion of α-ketoglutarate to succinyl-CoA and produces NADH directly providing electrons for the respiratory chain.
Is alpha-ketoglutarate gluconeogenesis?
Gluconeogenesis is the formation of glucose from precursors such as pyruvate, lactate, glycerol and alpha keto acids (carbon skeleton of amino acids is used for glucose). It takes place in the cytosol and mitochondria.