How is Ceftolozane-tazobactam administered?
The recommended dosage regimen of ZERBAXA (ceftolozane/tazobactam) for Injection is 1.5 g (1 g/0.5 g) administered every 8 hours by intravenous infusion over 1 hour in patients 18 years or older and with normal renal function or mild renal impairment.
What drug class is Ceftolozane-tazobactam?
Ceftolozane is in a class of antibiotics called cephalosporins. It works by killing bacteria. Tazobactam is in a class called beta-lactamase inhibitor. It works by preventing bacteria from destroying ceftolozane.
How do you reconstitute Zerbaxa?
Constitute each vial of ZERBAXA with 10 mL of sterile water for injection or 0.9% Sodium Chloride for Injection, USP and gently shake to dissolve. The final volume is approximately 11.4 mL per vial. Caution: The constituted solution is not for direct injection.
Is ceftolozane a cephalosporin?
Conclusion: Ceftolozane-tazobactam is a new cephalosporin with enhanced activity against multidrug-resistant P. aeruginosa and other gram-negative pathogens.
Does Zerbaxa cover enterococcus?
NOT ACTIVE against serine carbapenemases (e.g. KPCs or MBLs), most anaerobic bacteria, Staphylococcus spp., and Enterococcus spp.
Does Zerbaxa cover staph?
Tedizolid (Sivextro), available oral or IV, and active against Gram-positive bacteria including Staphylococcus aureus (including methicillin-resistant [MRSA] and methicillin-susceptible [MSSA] isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus Group (including Streptococcus inosus.
What does Zerbaxa treat?
Zerbaxa is an antibiotic used to treat adults with: • complicated (difficult to treat) infections of tissues and organs within the belly (intra-abdominal infections); serious kidney infection (acute pyelonephritis); • complicated infections of the urinary tract (structures that carry urine, such as the bladder);
Does Zerbaxa cover Esbl?
Ceftolozane-tazobactam (Zerbaxa) Tazobactam can prevent many ESBLs and cephalosporinases from impacting ceftolozane, but less so for AmpC beta-lactamases or carbapenemases.
Can you take ceftriaxone and tazobactam?
CEFTRIAXONE+TAZOBACTAM belongs to a class of medication called ‘antibiotics’ used to treat several bacterial infections of the urinary tract, blood, bones and joints, heart, brain, chest, ears, skin or soft tissues. The bacterial infection is a condition in which harmful bacteria grows in the body and cause infection.
What is Ceftriaxone injection used for?
Ceftriaxone injection is used to treat certain infections caused by bacteria such as gonorrhea (a sexually transmitted disease), pelvic inflammatory disease (infection of the female reproductive organs that may cause infertility), meningitis (infection of the membranes that surround the brain and spinal cord), and …
When do you use Recarbrio?
Recarbrio is a combination medicine that is used to treat complicated infections of the urinary tract (bladder and kidneys) or infections within the stomach area (abdomen). Recarbrio is also used to treat pneumonia (a lung infection) caused by being in a hospital or using a ventilator.
How much Ceftolozane is in a Zerbaxa vial?
ZERBAXA (ceftolozane/tazobactam) for Injection is supplied as a white to yellow sterile powder for reconstitution in single-use vials; each vial contains 1 g ceftolozane (equivalent to 1.147 g of ceftolozane sulfate) and 0.5 g tazobactam (equivalent to 0.537 g of tazobactam sodium).
Does ceftolozane interact with other medications?
No drug-drug interaction was observed between ceftolozane and tazobactam in a clinical study in 16 healthy subjects. In vitro and in vivo data indicate that ZERBAXA is unlikely to cause clinically relevant drug-drug interactions related to CYPs and transporters at therapeutic concentrations.
What is the dosage for ceftolozane 500 mg?
single loading dose of ceftolozane/tazobactam 750 mg (500 mg/250 mg) followed by a 150 mg (100 mg/50 mg) maintenance dose administered intravenously every 8 hours for the remainder of the treatment period (on hemodialysis days, administer the dose at the earliest possible time following completionof dialysis)
What is the binding percentage of ceftolozane to human plasma?
The binding of ceftolozane and tazobactam to human plasma proteins is approximately 16% to 21% and 30%, respectively. The mean (CV%) steady-state volume of distribution of ZERBAXA in healthy adult males (n = 51) following a single 1 g/0. 5 g (ceftolozane/tazobactam) intravenous dose of ZERBAXA was 13. 5 L (21%) and 18.