How experimental autoimmune encephalomyelitis is mediated in mice?
In mice. Demyelination is produced by injection of brain extracts, CNS proteins (such as myelin basic protein), or peptides from such protein emulsified in an adjuvant such as complete Freund’s adjuvant. The presence of the adjuvant allows the generation of inflammatory responses to the protein/peptides.
What is EAE immunology?
Experimental autoimmune encephalomyelitis (EAE) is a T-helper (Th) cell-mediated autoimmune disease characterized by T-cell and monocyte infiltration in the central nervous system (CNS) associated with local inflammation.
What is autoimmune encephalomyelitis model?
Abstract. Experimental autoimmune encephalomyelitis (EAE) is a model of the neuroimmune system responding to priming with central nervous system (CNS)-restricted antigens. It is an excellent model of post-vaccinal encephalitis and a useful model of many aspects of multiple sclerosis.
How does EAE model work?
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis. This model is produced by administering a myelin basic protein peptide (MBP) fragment that induces an autoimmune response directed to the myelin sheath surrounding motor neurons.
How is EAE induced in mice?
Experimental autoimmune encephalomyelitis (EAE) can be induced in SJL mice by immunization with proteolipid protein (PLP), myelin basic protein (MBP), or peptides corresponding to the immunodominant epitopes of MBP (MBP84-104), MOG (MOG92-106), or PLP (PLP139-151 and PLP178-191).
Is EAE a model of MS?
Experimental autoimmune encephalomyelitis (EAE) is the most commonly used experimental model for the human inflammatory demyelinating disease, multiple sclerosis (MS).
Is EAE similar to MS?
EAE is primarily used as an animal model of autoimmune inflammatory diseases of the CNS, and it resembles MS, the prototypical such disease, in many respects (Gold et al., 2006; Steinman and Zamvil, 2005; 2006; Farooqi et al., 2010).
Can ITE students go university?
ITE training has become a practical and viable alternative route to tertiary education. At every course level, ITE has created opportunities for graduates to progress to higher level training both internally and externally. Please refer to JPAE website for more information on progression to diploma courses.