How does adriamycin cause heart failure?
This increase in endothelin-1 caused by doxorubicin potentiates the increased calcium load in cardiomyocytes, thereby facilitating apoptosis and cardiac dysfunction. Clinically, patients with doxorubicin-induced congestive heart failure also have increased levels of endothelin-1.
How does adriamycin affect the heart?
Cardiotoxicity means permanent damage to the muscles of the heart or the functioning of the heart. Cardiotoxicity can be severe with Adriamycin treatment and may develop late during therapy, or within two to three months after the treatment has ended.
How does doxorubicin cause cardiotoxicity?
Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes.
Does adriamycin cause heart problems?
Unfortunately, its use has been hampered by conventional toxicities and cardiotoxicity manifested by congestive cardiomyopathy. Adriamycin is particularly toxic to heart tissue and constitutes a major cause of morbidity and mortality due to its complex pathogenesis.
Can doxorubicin cause heart failure?
Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular dysfunction, and also induce late-onset cardiomyopathy and heart failure. Despite extensive studies, the pathogenic sequelae leading to the progression of Dox-associated cardiomyopathy remains unknown.
What is adriamycin induced cardiomyopathy?
Adriamycin is an antineoplastic agent used in a wide variety of malignancies. Its use is limited because of a cumulative, dose-dependent irreversible cardiomyopathy. We report a case of adriamycin-induced cardiomyopathy, after he had undergone chemotherapy for Hodgin lymphoma.
What is the mechanism of doxorubicin?
Mechanisms of anticancer pharmacodynamics There are two proposed mechanisms by which doxorubicin acts in the cancer cell (i) intercalation into DNA and disruption of topoisomerase-II-mediated DNA repair and (ii) generation of free radicals and their damage to cellular membranes, DNA and proteins (shown in Fig. 1) [9].
What are the long-term side effects of Adriamycin?
Long-term gastrointestinal side effects that have been reported with Adriamycin include:
- Gastric ulcers or erosions.
- Hyperpigmentation of the tongue or oral mucosa (rare)
- Ulceration and necrosis of the colon, especially the cecum (rare).
Which is the most serious side effect of doxorubicin?
This medicine may cause irreversible heart muscle damage, leading to heart failure. This is more likely to occur if you have other heart problems, have had or currently receiving radiation therapy to your chest, or have received other cancer medicines.