How do you calibrate a DT apparatus?
B) Calibration for Temperature Maintenance
- Set the temperature to 37°C.
- Fill the beaker with water.
- Attach the basket rack assembly & start the constant frequency of moving up & down.
- Insert the calibrated thermometer in one of the tubes of the basket rack assembly.
- Wait till temperature reaches between 36°C to 38°C.
What are the acceptable criteria for tablet disintegration?
The test is met if all of the dosage units have disintegrated completely. If 1 or 2 dosage units fail to disintegrate, repeat the test on 12 additional dosage units. The test is met if not less than 16 of the total of 18 dosage units tested are disintegrated.
How do you check disintegration?
Remove the assembly from the liquid. The disintegrating tablets or capsules pass the test if all of them have disintegrated. If 1or 2 tablets or capsules fail to disintegrate, repeat the test on 12 additional tablets or capsules; not less than 16 of the total of 18 tablets or capsules tested disintegrate.
What is the operating temperature for disintegration test?
37±
Why the temperature specification for disintegration test apparatus is 37±2 ºC. Why it is different from that of dissolution test apparatus (37±0.5 ºC)? Though both mimics the body conditions to which the formulation will be exposed after administration.
What is disintegration test apparatus?
Tablet Disintegration Test Apparatus is microprocessor based instrument designed to be used by pharmaceutical industry for accurate determination time of tablets and capsules as per IP/BP/USP standards, The Disintegration Test Apparatus helps in evaluation of disintegration capability of formulations (ex: tablets) and …
How do you balance calibration?
Record the observations in the calibration log. Place standard weight equivalent to 30 % of maximum capacity in four corners and center of the balance and note down the readings in record. Calculate % Relative Standard Deviation (RSD). Record the observations in the balance calibration record.
What is the process of disintegration?
Definition of disintegration : the act or process of disintegrating or the state of being disintegrated: such as. a : the breaking down of something into small particles or into its constituent elements Some glaciers have been destabilized by warmer ocean waters.
Why disintegration test is done?
The disintegration test is used to show how quickly the tablet breaks down into smaller particles, allowing for a greater surface area and availability of the drug when taken by a patient.
What is weighing scale calibration?
Weighing Scale Calibration is a set of processes under controlled conditions that show the relationship between the values of quantities using measurement and the corresponding values according to standards set.
What is a calibrated scale?
Scale calibration is a procedure that ensures that a weighing scale or balance delivers correct, accurate weighing results to the degree specified on the scale. The accuracy of weighing scales can diminish over time through regular use, dust build-up or age; a process often referred to as ‘drift’.