Does trehalose stimulate autophagy?
The disaccharide trehalose is commonly considered to stimulate autophagy. Cell treatment with trehalose could decrease cytosolic aggregates of potentially pathogenic proteins, including mutant huntingtin, alpha-synuclein and phosphorylated tau that are associated with neurodegenerative diseases.
What is trehalose (mycose)?
Trehalose, also known as mycose, is a natural disaccharide found extensively but not abundantly among several organisms. It is described that trehalose can work as an important autophagy modulator and can be proficiently used in the control several diseases in which autophagy plays an important role.
What is trehalose used for?
Background: Trehalose is a disaccharide with protein stabilizing and autophagy enhancing properties. It showed efficacy in reducing abnormal protein aggregation in animal models of several human poly A- and poly Q- mediated hereditary neurological disorders (of which OPMD is an example).
Does trehalose block autolysosomal clearance of lysosomes?
Trehalose (THL) blocks autolysosomal clearance. ( a) Trehalose (48 h treatment) and BafA1 (Baf; 12 h treatment) increase p62 and LC3-II levels in cells, respectively. ( b) CQ (24 h), a lysosome-disrupting agent, also increases p62 and LC3-II forms.