Can eplerenone cause gynecomastia?
A selective aldosterone antagonist (eplerenone) has a lower incidence of gynecomastia, but the cost is higher.
Does eplerenone block testosterone?
Conclusions: Testosterone appears to have a protective effect against cardiomyocyte apoptosis which is antagonized by spironolactone but not by eplerenone. These effects await confirmation in in vivo models, but their presence could have clinical and therapeutic implications.
What drugs cause gynecomastia?
The drugs definitely associated with the onset of gynecomastia are spironolactone, cimetidine, ketoconazole, hGH, estrogens, hCG, anti-androgens, GnRH analogs and 5-α reductase inhibitors.
Which diuretic causes gynecomastia?
Furosemide, a loop diuretic, also indicated in congestive heart failure, is also reported to cause gynecomastia.
What are the side effects of eplerenone?
Side Effects
- Abdominal or stomach pain.
- arm, back, or jaw pain.
- chest pain or discomfort.
- chest tightness or heaviness.
- difficulty with breathing.
- fast or irregular heartbeat.
- irregular heartbeat.
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs.
Can drug induced gynecomastia be reversed?
Iatrogenic gynecomastia is generally reversible within 6 months or one year since its onset. If drug discontinuation is not enough or not possible (for example with anti-androgens), a therapy based on tamoxifene (20 mg daily) might be taken into consideration.
Is eplerenone a steroid?
It is a steroidal antimineralocorticoid of the spirolactone group and a selective aldosterone receptor antagonist (SARA). Eplerenone is more selective than spironolactone at the mineralocorticoid receptor relative to binding at androgen, progestogen, glucocorticoid, or estrogen receptors.
Do Gyno pills work?
No supplements are proven to treat gynecomastia No supplements, including Ayurveda herbs, have been scientifically proven to treat gynecomastia. The Food and Drug Administration (FDA) also hasn’t approved any medications for the treatment of gynecomastia.
What is the best drug for gynecomastia?
Tamoxifen, an estrogen antagonist, is effective for recent-onset and tender gynecomastia when used in doses of 10-20 mg twice daily. Up to 80% of patients report partial to complete resolution. Tamoxifen is typically used for 3 months before referral to a surgeon.
Can BP meds cause gynecomastia?
Angiotensin-converting enzyme inhibitors, spironolactone, digoxin, amiodarone, verapamil, diltiazem, and nifedipine are the medications commonly used in Cardiology practice and they are all reported to be the cause of gynecomastia.
Does eplerenone cause hair loss?
Eplerenone has a higher affinity for the aldosterone receptor than spironolactone and is claimed to have fewer anti-androgenic effects (gynecomastia, hair loss). However, the two molecules are structurally quite similar.