Are there heavy metals in prescription drugs?
The products contained variable amounts of heavy metals as of 0.0017 to 11.88 μg lead; 0.0011 to 0.5559 μg cadmium and 0.0011 to 2.6428 μg nickel, respectively.
Which particle is ideal for pharmaceutical application?
Tightly controlled particle size distributions are highly important for pharmaceutical drug development. Powder particle size distribution is a valuable indicator of quality and performance.
What is contamination in pharmaceutical industry?
Contamination is defined as the undesired introduction of impurities of a chemical or microbiological nature, or of foreign matter, into or onto a raw material, intermediate, or API (Active Pharmaceutical Ingredient) during production, sampling, packaging or repackaging, storage or transport.
What is particle size analysis in pharmaceutical industry?
The purpose of particle size analysis is to obtain quantitative data on the mean size, particle size distribution (PSD) and shape of the compounds to be used in pharmaceutical formulation. The particle size analysis is also required to assure the quality of the final dosage forms and drug delivery systems.
What are foreign particles?
Most often, foreign particles contaminating a product have a composition that differs from that of the product itself, so the common method of foreign particle analysis is composition analysis. It may not be possible to designate or identify this insect as a foreign particle just with composition analysis.
What are inherent particles?
Inherent particles are defined as materials that are expected from the drug formulation, and thus represent a generally accepted characteristic of the product.
Why is particle size important in formulation?
Particle size is a crucial parameter in the pharmaceutical industry, because it influences surface area and porosity and, hence, has an impact on bioavailability, effectiveness and shelf life of a drug. Particle size also greatly affects tableting and granulation processes.
How does particle size affect drugs may?
The size, distribution and shape of the particles can affect bulk properties, product performance, processability, stability and appearance of the end product. The link between particle size and product performance is well documented with regards to dissolution, absorption rates and content uniformity.
What metals are used in pharmaceuticals?
These three metals are used in modern medicine:
- Iron. Iron is one of the most vital minerals in our bodies, and medical applications are mined from iron ore.
- Zinc. Zinc is a metal found in every tissue of the body.
- Platinum.
What are heavy metals in drugs?
Historically, the most likely culprits for trace metals in drug products were arsenic, cadmium, lead and mercury, all of which are much more likely to enter the manufacturing chain from natural sources.
What is the importance of particles?
In the atmosphere, small particles impact both warming and cooling of the climate. In Earth’s subsurface, small particles impact soil and water quality. In living systems, small particles impact organism health and viability. In catalysis and reaction engineering, small particles enhance reaction specificity and rates.
What is the importance of particle analysis in pharma manufacturing?
Particle size is a crucial parameter in the pharmaceutical industry, because it influences surface area and porosity and, hence, has an impact on bioavailability, effectiveness and shelf life of a drug.