Can you take Plavix and PPI together?
Antiplatelet medication Plavix (clopidogrel) and heartburn-relieving proton pump inhibitors (PPIs) are commonly taken together. PPIs can make Plavix less effective, potentially raising your risk of a heart attack or stroke.
Should a PPI be prescribed with clopidogrel?
Previous advice regarding an interaction In May 2009, the EU Committee for Medicinal products for Human Use (CHMP) concluded that concomitant use of any PPIs with clopidogrel should be avoided unless considered essential.
What happens if you take clopidogrel and omeprazole together?
Concomitant use of omeprazole and clopidogrel was found to decrease the exposure (AUC) to clopidogrel’s active metabolite by 50% and to sharply increase platelet reactivity, as a result of inhibition by omeprazole of CYP2C19, a cytochrome P450 (CYP) enzyme.
Can clopidogrel and pantoprazole be taken together?
clopidogrel pantoprazole Combining these medications may reduce the effectiveness of clopidogrel in preventing heart attack or stroke. The interaction is most likely to occur if you are using a higher dosage of pantoprazole than recommended or if you are using it too frequently.
What acid reducer can be taken with Plavix?
The FDA advises that if you are experiencing heartburn or acid reflux while taking Plavix, you should try using antacids ( Maalox, Mylanta, Rolaids, Tums and generics) and most H2 blockers such as famotidine (Pepcid), nizatidine (Axid) and ranitidine (Zantac), but not cimetidine (Tagamet, Tagamet HB, and generics).
What medications interact with clopidogrel?
Clopidogrel may interact with other medications
- Diabetes drug. In most cases, repaglinide should not be taken with clopidogrel.
- Stomach acid drugs (proton pump inhibitors)
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Blood thinners.
- Drugs used to treat depression.
- Salicylates (aspirin)
- Opioids.
Can I take omeprazole while on Plavix?
FDA is recommending that the co-administration of clopidogrel (Plavix), a drug used to prevent blood clot formation, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid, be avoided because omeprazole reduces the effectiveness of clopidogrel.
Can I take aspirin and Plavix together?
aspirin clopidogrel This combination may cause unusual bleeding, severe abdominal pain, weakness, and the appearance of black, tarry stools. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment if you take both medications.