What is the most common side effect from sulfonylurea medication?
Sulfonylureas are usually well tolerated. The most common side effect is hypoglycemia, more common with long-acting sulfonylureas such as chlorpropamide and glibenclamide [23–25]. However, all sulfonylureas may cause hypoglycemia, usually due to an excessive dosage.
Who should not take sulfonylureas?
Sulfonylurea Precautions Sulfonylureas shouldn’t be taken by people with type 1 diabetes or diabetic ketoacidosis (a dangerous condition that can occur if high blood sugar is left untreated). People with liver or kidney problems may not be able to take sulfonylureas.
How long does it take for sulfonylureas to stop working?
Table 1
| Class of hypoglycemic agents | Duration of action | Reduction in FPG (mg/dL) |
|---|---|---|
| Sulfonylureas | 12–24 hours | 60–70 |
| Glyburide | Up to 24 hours | |
| Glipizide | 6–12 hours | |
| Gliclazide | 12 hours |
Why do sulfonylureas cause weight gain?
Like insulin, sulfonylureas can induce weight gain, mainly as a result of their effect to increase insulin levels and thus utilization of glucose and other metabolic fuels. Other side-effects are: gastrointestinal upset, headache and hypersensitivity reactions.
Why are sulfonylureas taken before meals?
Sulfonylureas. Sulfonylurea drugs are used in patients with type 2 DM in whom diet alone is insufficient to achieve glycemic control. They are absorbed from the gastrointestinal tract where food can interfere with their absorption, so sulfonylureas with short half-lives should be taken 30 minutes before eating.
Does sulfonylurea cause erectile dysfunction?
Doctor’s response. Glyburide is a sulfonylurea oral medication used in lowering blood glucose in patients with type II diabetes mellitus. It does not usually cause impotence. However, nerve damage and blood vessel disease related to diabetes can cause impotence.
How does sulfonylureas work in the body?
How do sulphonylureas work? Sulphonylureas are insulin secretagogues, which means they work by causing the body to secrete insulin. Another class of diabetes drugs which works in this way is the prandial glucose regulators class.