How effective is micafungin?
Several clinical trials involving micafungin have demonstrated its efficacy in IC, reporting response rates ranging from 71–90% [12–15]. Micafungin has also shown efficacy when used as a prophylactic agent for fungal infections in neutropenic patients [6, 16].
Is voriconazole better than fluconazole?
Visual disturbances and abnormal liver function test results were more common in the voriconazole group. The authors concluded that voriconazole is at least as effective as fluconazole for the treatment of esophageal candidiasis.
Does micafungin cover Candida albicans?
Micafungin is an effective antifungal agent useful for the therapy of invasive candidiasis. Candida albicans is the most common cause of invasive candidiasis; however, infections due to non-C.
When do you use micafungin?
Micafungin injection is used to help the body overcome serious fungus infections, such as candidemia, acute disseminated candidiasis, candida peritonitis and abscess without meningoencephalitis or ocular dissemination, and esophageal candidiasis.
Is mycamine the same as micafungin?
Micafungin, sold under the brand name Mycamine, is a echinochandin antifungal medication used to treat and prevent invasive fungal infections including candidemia, abscesses and esophageal candidiasis.
Does micafungin cover aspergillosis?
Micafungin demonstrates in vitro and in vivo activity against Aspergillus spp. It is currently not licensed to treat Aspergillus infections in the UK or USA.
How long does it take for micafungin to work?
Cover the IV bag during your infusion to protect the medicine from light. Use the medicine within 24 hours after mixing. Micafungin must be given slowly through an IV infusion, and each injection can take at least 1 hour to complete.
Is micafungin fungistatic?
Available data support its efficacy in the treatment of esophageal and systemic candidiasis. Against Aspergillus species, the drug is “fungistatic”; however, open-trial data have suggested that micafungin might be useful in the treatment of refractory aspergillosis.
Can you take voriconazole with fluconazole?
Although no safety issues were observed during coadministration, concomitant use of fluconazole and voriconazole is not recommended. Frequent monitoring for voriconazole-related adverse events is advisable if voriconazole is used sequentially after fluconazole.
What is voriconazole used to treat?
Voriconazole is used to treat serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia (fungal infection in the blood), esophageal candidiasis (candida esophagitis), or other fungal infections (infections in the skin, stomach, kidney, bladder, or wounds).
Is micafungin renally dosed?
Patients with renal impairment: Severe renal impairment (Glomerular Filtration Rate [GFR] < 30 ml/min) did not significantly affect the pharmacokinetics of micafungin. No dose adjustment is necessary for patients with renal impairment.
Is micafungin 100 mg a safe and effective alternative to caspofungin?
The results of this trial indicate that micafungin 100 mg daily is a safe and effective alternative to both micafungin 150 mg daily and a conventional dosage of caspofungin in the treatment of candidemia and other forms of invasive candidiasis.
How effective is micafungin for the treatment of candidaemia and invasive candidosis?
Micafungin was as effective as–and caused fewer adverse events than–liposomal amphotericin B as first-line treatment of candidaemia and invasive candidosis. Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial Lancet.
Is micafungin as effective as amphotericin B?
In addition, micafungin is as effective as liposomal amphotericin B and caspofungin for the treatment of invasive candidiasis/candidemia. Notably, fewer adverse effects were observed for micafungin compared to liposomal amphotericin B in both adults and pediatric patients.
Is micafungin protein-bound?
Similar to anidulafungin and caspofungin, micafungin is extensively protein-bound in the plasma (>99.5%) (Mycamine 2008). The effects of protein binding on the activity of echinocandins are not fully understood as studies on the effects of protein binding on echinocandin activity have reported conflicting results.
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