What is a beta-2-transferrin test?
In summary, the beta-2-transferrin assay is a highly sensitive and specific test for the presence of CSF in body fluids. This test has been employed successfully by otolaryngologists in the diagnosis of skull-base CSF leaks.
Is a beta-2-transferrin test accurate?
Conclusions The β2-transferrin assay is a reliable method for confirming suspected CSF and should be used as a primary screening method in all patients with suspected CSF leakage.
Where is beta-2-transferrin found?
cerebrospinal fluid
Beta-2-transferrin is a protein produced by neuraminidase activity in the brain which is uniquely found in the cerebrospinal fluid (CSF) and perilymph. Its absence in other body secretions makes its detection invaluable in diagnosing a CSF leak.
How is a CSF leak treated?
The CSF leak is repaired using your own tissue from the nose or with a biomaterial graft. Length of stay in the hospital depends on the size of the leak — most patients are in the hospital for a few days after surgery. Some patients may require a lumbar drain that is removed before going home.
How do you test for CSF rhinorrhea?
CT myelography. This test is considered the gold standard for diagnosing and locating CSF leaks. It uses a CT scan and a contrast dye to locate CSF leaks anywhere in the skull base. It provides the most precise location of a CSF leak and helps to determine the most appropriate treatment plan.
What is CSF fluid leak?
Cerebrospinal fluid (CSF) leak occurs when there is a tear or hole in the membranes surrounding the brain or spinal cord, allowing the clear fluid that surrounds and cushions those organs to escape.
What is tau transferrin?
Tau protein is sometimes used to describe an asialylated form of transferrin which is present in CSF but absent in serum. The detection of this protein in nasal fluids indicates that the fluid originated from the CNS.
What is Beta-2 microglobulin blood test?
What is a beta-2 microglobulin tumor marker test? This test measures the amount of a protein called beta-2 microglobulin (B2M) in the blood, urine, or cerebrospinal fluid (CSF). B2M is a type of tumor marker. Tumor markers are substances made by cancer cells or by normal cells in response to cancer in the body.
Is a CSF leak serious?
A CSF leak is very dangerous and potentially life-threatening as it can lead to meningitis. For a condition as serious as a CSF leak, you should consult with a sinus specialist immediately to begin the proper treatment.
What is the normal CSF glucose level?
Normal Results The glucose level in the CSF should be 50 to 80 mg/100 mL (or greater than 2/3 of the blood sugar level).
What does transferrin mean in a blood test?
A transferrin test is carried out to directly measure the level of iron in the blood and also the body’s ability to transport iron in the blood. The transferrin blood test is ordered if the doctor suspects abnormalities of iron levels in your body. The tests help diagnose chronic iron overload or deficiency.
How do you test CSF Halo?
To perform the test, the leaking fluid is dripped onto a 4×4 gauze or towel. Positive results are indicated by blood coalescing into the center, leaving an outer ring of cerebrospinal fluid….
| Halo sign | |
|---|---|
| Differential diagnosis | temporal arteritis |