What does it mean if a drug has a narrow therapeutic window?
Some drugs have a narrow therapeutic index, which means that there is only a small difference between the minimum effective concentrations and the minimum toxic concentrations in the blood. With such drugs, small increases in dose or in blood/serum concentrations could lead to toxic effects.
Which drug has a very powerful effect in the elderly and has a narrow therapeutic window?
Because of its narrow therapeutic window, digoxin requires close monitoring. Also, two major drawbacks of digoxin are its adverse effects (AEs) and multiple drug interactions.
Does warfarin have a narrow therapeutic window?
Warfarin has been in clinical use for nearly 60 years, and in 2010 there were over 25 million prescriptions for warfarin in the U.S. While warfarin is highly efficacious, it has a narrow therapeutic window to achieve desired anticoagulation without excess risk of bleeding.
Does ibuprofen have a narrow therapeutic index?
The maximum recommended daily dose is 3200 mg, and the therapeutic window of ibuprofen is wide: 10-50 mg/L and the toxic concentration is high (>100 mg/L).
What are the narrow drugs?
Narrow therapeutic index drugs are drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are life-threatening or result in persistent or significant disability or incapacity.
Why does digoxin have a narrow therapeutic index?
The narrow therapeutic range of digoxin means that small variations in blood concentration may easily result in toxic or sub therapeutic concentrations. To maintain concentrations within the therapeutic range requires consistent bioavailability and careful management of factors that may influence bioavailability.
Does amiodarone have a narrow therapeutic index?
Amiodarone is difficult to administer because of its narrow toxic-therapeutic range and prolonged loading phase. More importantly, the first sign of antiarrhythmic failure may be manifest as sudden cardiac death.
Is theophylline a narrow therapeutic index drug?
Theophylline has an extremely narrow therapeutic window. Therefore, Theophylline toxicity occurs when serum theophylline levels surpass the levels in the therapeutic range.
Does aspirin have a narrow therapeutic index?
Most readers would not consider aspirin or another salicylate as a nar- row therapeutic index drug. However, when used in large doses to treat inflammatory disease, it is a narrow thera- peutic index drug because of its nonlinear elimination kinetics in humans.
Is warfarin a narrow therapeutic index?
Not only does warfarin exhibit a narrow therapeutic index, but there can be 10 to 20-fold differences in the warfarin dose required to achieve target INR.
Does carbamazepine have a narrow therapeutic index?
Background and objectives: Carbamazepine is among those drugs that have been considered to have a narrow therapeutic plasma concentration range, that is, a narrow therapeutic index.