Is Carcinoma ex pleomorphic adenoma a carcinomatous change?
Background: Carcinoma ex pleomorphic adenoma (CA-ex-PA) is extremely unusual in minor salivary glands of oral cavity. CAex-PA is a carcinomatous change as a primary or as a recurrence of pleomorphic adenoma.
What is ex pleomorphic salivary gland cancer?
Carcinoma ex pleomorphic adenoma is a high-grade salivary gland carcinoma in which malignant transformation occurs in a previously benign pleomorphic adenoma. This tumor most often develops in the parotid gland, where it represents 2% to 3% of all parotid neoplasms.
What is included in the diagnosis of pleomorphic adenoma?
Identification of both malignant and benign components is essential for diagnosis; in cases where the benign component has been obliterated by carcinoma, a history of pleomorphic adenoma at the site must be documented Typical clinical presentation is a longstanding palpable mass in the parotid region that has undergone recent rapid growth
What is the prognosis of pleomorphic adenoma of the lung?
Such malignant change often is discovered incidentally upon microscopic examination of a lesion thought to represent a pleomorphic adenoma. If only minimal extracapsular invasion is present (≤1.5 mm), the prognosis also is excellent, with a 5-year survival rate of 98%. In contrast, tumors showing wider invasion have a much more guarded prognosis.