What is the purpose of ectopic expression?
Ectopic expression of E2F1 induces DNA synthesis in quiescent immortal rodent cells, confers neoplastic properties to immortalized cells, and increases tumorigenesis in transgenic mice that lack p53 function.
What does ectopic mean in biology?
Ectopic is a word used with a prefix, ecto, meaning “out of place.” Ectopic expression is an abnormal gene expression in a cell type, tissue type, or developmental stage in which the gene is not usually expressed.
What is ectopic transcription?
Ectopic (or illegitimate) transcription is the very low level of transcription of ’tissue-specific’ genes in cell types lacking obvious requirement for the gene product.
How can you produce ectopic expression of a gene?
The occurrence of gene expression in a tissue in which it is normally not expressed. Such ectopic expression can be caused by the juxtaposition of novel enhancer elements to a gene during genetic manipulation of transgenic organisms.
What is heterologous gene expression?
Heterologous expression refers to the expression of a gene or part of a gene in a host organism which does not naturally have this gene or gene fragment. After being inserted in the host, the gene may be integrated into the host DNA, causing permanent expression, or not integrated, causing transient expression.
Is ectopic pregnancy genetic?
Ectopic pregnancy (the name of the condition when the fertilized egg fails to nest in the uterus or womb) is not something that can be inherited, so the fact that you may share some of your sister`s genes doesn`t place you at greater risk.
What could the leaking of construct or ectopic gene expression cause?
Undesirable leaky (ectopic) expression in organs or tissues may result in unexpected phenotypes. In case the transgene is integrated into multiple chromosomes, further crossing with wild-type mice is necessary for the transgene to be segregated into different chromosomes to establish separate mouse lines.
What is over expression?
In biology, to make too many copies of a protein or other substance. Overexpression of certain proteins or other substances may play a role in cancer development.
What is the purpose of overexpressing a gene?
Is gene expression the same as protein expression?
In several articles, you can find that the authors refer to the amount of protein as “protein expression”. When it is the case of mRNA amount, also is referred as “expression” (gene expression).