What is Juxtacanalicular tissue?
Juxtacanalicular tissue (also known as the cribriform meshwork) – Lies immediately adjacent to Schlemm’s canal, composed of connective tissue ground substance full of glycoaminoglycans and glycoproteins. This thin strip of tissue is covered by a monolayer of endothelial cells.
What is the trabecular?
The trabecular meshwork is a tissue located in the anterior chamber angle of the eye, and it is a crucial determinant of intraocular pressure values because of its resistance to the evacuation of aqueous humor from the eye.
What is the Uveoscleral pathway?
Share: The term uveoscleral outflow refers to the drainage of ocular aqueous humor from the anterior chamber into the anterior chamber angle other than through the trabecular meshwork (Figure). Unlike the trabecular outflow route, the uveoscleral outflow route is not a distinctive pathway with tubes and channels.
What is the human trabecular meshwork?
Human Trabecular Meshwork Cells (HTMC) are endothelial-like cells in a sponge-like connective tissue located near the front of the eye. In this area of high outflow resistance, HTMC regulate eye pressure by controlling drainage of fluid into tubes that flow into the bloodstream.
Where is Schlemm’s canal?
The Schlemm’s canal (SC), named after the German anatomist, Friedrich Schlemm and first identified in 1830 [1], is a unique, ring-shaped, endothelium-lined vessel that encircles the cornea [2,3] (Figure 1). Anatomically, it is situated directly against the juxtacanalicular (JCT) region of the trabecular meshwork (TM).
What is glaucoma Slideshare?
Definition • It is not one disease but rather a group of disorder characterized by 1. Increased IOP and the consequences of elevated pressure, 2. Optic nerve atrophy 3. Peripheral visual field loss.
How does Uveoscleral increase outflow?
The uveoscleral outflow is decreased by contraction (pilocarpine) and increased by relaxation (atropine) of the ciliary muscle. Thus, changing the tone of the ciliary muscle may redistribute aqueous humour between the conventional and uveoscleral outflow routes.
How does epinephrine increase Uveoscleral outflow?
Epinephrine increases uveoscleral flow, most likely through stimulating beta(2)-adrenergic receptors. Prostaglandin F(2alpha) and prostaglandin F(2alpha)-analogues effectively reduce intraocular pressure by increasing uveoscleral flow.
How many types of glaucoma are there?
The two main types are open-angle and angle-closure. These are marked by an increase of intraocular pressure (IOP), or pressure inside the eye.