What causes Type 2 hyperlipoproteinemia?
Type IIb hyperlipoproteinemia is caused by mutation in the receptor-binding domain of APOLIPOPROTEIN B-100 which is a major component of LOW-DENSITY LIPOPROTEINS and VERY-LOW-DENSITY LIPOPROTEINS resulting in reduced clearance of these lipoproteins.
What is Type 2 hypercholesterolemia?
Familial hypercholesterolemia (FH), also known as familial hyperlipoproteinemia type 2 or Fredrickson class 2a hyperlipidemia, is an autosomal dominant-inherited genetic disorder that leads to elevated blood cholesterol levels. Typically, the patient inherits only 1 of the defective genes, making him heterozygous.
What is the difference between hyperlipoproteinemia and hyperlipidemia?
Hyperlipoproteinemia refers to a group of acquired and inherited disorders whose common denominator is excessive levels of lipids (fats) in the blood, caused by a metabolic disorder. It is also referred to as hyperlipidemia.
What occurs in type I Hyperlipoproteinemia?
Type I hyperlipoproteinemia is the best-characterized genetic cause of hypertriglyceridemia and is caused by a deficiency or defect in either the enzyme lipoprotein lipase or its cofactor, apo C-II.
Is hypercholesterolemia the same as hyperlipidemia?
Hyperlipidemia means your blood has too many lipids (or fats), such as cholesterol and triglycerides. One type of hyperlipidemia, hypercholesterolemia, means you have too much non-HDL cholesterol and LDL (bad) cholesterol in your blood.
What is cause of high triglycerides?
Cause. The most common causes of high triglycerides are obesity and poorly controlled diabetes. If you are overweight and are not active, you may have high triglycerides, especially if you eat a lot of carbohydrate or sugary foods or drink a lot of alcohol.
What is Hyperlipoproteinemia familial 3?
Familial type III hyperlipoproteinemia(HLP) is characterized by increased plasma triglyceride(TG) and plasma remnant lipoproteins(chyromicron remnants and VLDL remnants i.e. IDL). Remnants predispose affected subjects to premature or accelerated atherosclerosis.
Which drug may cause Hyperlipoproteinemia?
Hyperlipoproteinemia, Primary Familial hypercholesterolemia: Statins, bile acid sequestrants, or niacin. Ezetimibe can be added to statins to achieve LDL goals.
Can high triglycerides be reversed?
Working toward a moderate body weight by consuming fewer excess calories can be an effective way to lower your blood triglyceride levels. In fact, research has shown that losing even 5–10% of your body weight can significantly reduce your triglyceride levels ( 3 ).