What is the difference between RotaTeq and Rotarix?
Rotarix is a live, monovalent, human attenuated vaccine given in 2 doses (one course) at 2 and 4 months of age. RotaTeq is a live, pentavalent, human–bovine reassortant vaccine given in 3 doses (one course) at 2, 4 and 6 months of age.
What type of vaccine is RotaTeq?
There are two rotavirus vaccines licensed for use in infants in the United States: RotaTeq® (RV5), which is given in three doses at 2 months, 4 months, and 6 months of age. Rotarix® (RV1), which is given in two doses at 2 months and 4 months of age.
Is RotaTeq a recombinant vaccine?
The trivalent NRRV vaccine candidate is composed of 3 recombinant protein antigens designed to protect against the most prevalent RV strains in the developing world (P[4], P[6], and P[8]). Each of these 3 antigens is a recombinant fusion protein based on the RV surface protein VP4.
Is RotaTeq a vaccine?
What is RotaTeq? RotaTeq is a vaccine manufactured by Merck and Co. Inc., (Merck) licensed by FDA in 2006 for the prevention of rotavirus gastroenteritis in infants 6 weeks to 32 weeks of age.
What is the RotaTeq?
RotaTeq is an oral vaccine used to help prevent rotavirus infection in children. Rotavirus infection can cause fever, vomiting, and diarrhea that can be severe and can lead to loss of body fluids (dehydration), hospitalization and even death in some children.
How effective is the RotaTeq vaccine?
In large clinical trials, RotaTeq® demonstrated 98% protection against severe rotavirus gastroenteritis (fever, vomiting, diarrhea, and changes in behavior), and 74% protection against gastroenteritis of any severity (inflammation of the stomach and intestine) caused by rotavirus through the first rotavirus season ( …
How do you use RotaTeq?
Both rotavirus vaccines are administered orally, by putting drops in the infant’s mouth. Each requires multiple doses: RotaTeq® (RV5) is given in three doses at 2 months, 4 months, and 6 months of age. Rotarix® (RV1) is given in two doses at 2 months and 4 months of age.
Where is RotaTeq manufactured?
The majority of the IS cases occurred in infants who were 4 months old or older at first vaccination. * human-bovine rotavirus reassortants (live), produced in Vero cells. Manufacturing process The active substance is manufactured at West Point, Pennsylvania, USA.
How do you administer RotaTeq?
What is the recommended schedule for RotaTeq vaccine?
RotaTeq (RV5; Merck) is recommended for routine oral administration for all infants as a 3-dose series. The usual schedule is at ages 2, 4, and 6 months. Rotarix (RV1; GlaxoSmithKline) is recommended as a 2-dose series at ages 2 and 4 months. The minimum interval between doses of rotavirus vaccine is 4 weeks.
What are the 4 key types of subunit vaccines?
Types
- Protein subunit.
- Polysaccharide subunit.
- Conjugate vaccine.
- Peptide subunit.
- Virus-like particles.
- Advantages.
- Disadvantages.
What is the most common adverse reaction to RotaTeq vaccine?
The most common side effects reported after taking RotaTeq were diarrhea, vomiting, fever, runny nose and sore throat, wheezing or coughing, and ear infection.