Does sevoflurane lower seizure threshold?
Sevoflurane has been shown to lower seizure threshold and has not been used in the treatment of status epilepticus; this agent probably should be avoided as it can induce epileptiform discharges in non-epileptic patients.
Which anesthetic agent is contraindicated in epilepsy?
For example, inhalational agents (such as isoflurane, halothane, desflurane) are not proconvulsive when administered alone [5]. To avoid epileptic events during procedures, anesthesia providers can consider using morphine and hydromorphone [3].
Which IV anesthetic should be avoided in the patient with a history of seizures?
For uncontrolled seizures, treatment with midazolam, thiopental, or propofol is acceptable; opioids should be avoided.
Is sevoflurane less potent than isoflurane?
Agents with nonoverlapping 95% confidence intervals are significantly different from each other ( i.e. , sevoflurane is more potent than isoflurane), as shown in table 2 .
Is anesthesia safe for epilepsy?
There is little risk of seizures during general anesthesia because anesthetic agents inhibit the firing of neurons, although the anesthetic sevoflurane can rarely precipitate seizures. There is generally no increased risk of seizures upon awakening from anesthesia if AEDs have been taken.
Does propofol stop seizures?
The dose of propofol required to control seizures was between 100-200 mg (1.5-3 mg/kg). There is an RCT that demonstrates significant shortening of seizure duration (both clinically and on EEG) with the use of propofol in the setting of electroconvulsive therapy.
Which of the following Anaesthetic agents can induce epilepsy?
Rapid induction of anesthesia occasionally can be associated with one or more acute seizures. Propofol,13 flurane (a substitute for halothane),14 and benzodiazepines (especially lorazepam)15 seem to be the agents implicated most often.
What is the difference between Keppra and Briviact?
Briviact (brivaracetam) and Keppra (levetiracetam) are anticonvulsant medicines that target the synaptic vesicle protein 2A (SV2A) in the brain. The newer agent Briviact is noted to be more selective and has a higher affinity for this receptor than Keppra.
What drug is contraindicated in patients with a history of seizures?
Flumazenil is contraindicated in patients with a history of seizures, but this may need to be re-evaluated in light of a recent study.
Is spinal anesthesia contraindicated in epilepsy?
Conclusions: We conclude that majority of seizures occurring in the perioperative period in patients with a preexisting seizure disorder are likely related to the patient’s underlying condition and that regional anesthesia in these patients is not contraindicated.
Is sevoflurane more potent than desflurane?
Sevoflurane is more expensive than desflurane but is more potent, is rapidly acting and also has faster emergence and recovery.