Is pseudoephedrine HCl soluble in water?
DEA Controlled Substance: A valid unexpired DEA license on file is required for purchase….PSEUDOEPHEDRINE HYDROCHLORIDE USP (30-1159)
| Test | Specification |
|---|---|
| MELTING POINT | 182-186 °C |
| PH | 4.6-6.0 |
| SOLUBILITY | VERY SOLUBLE IN WATER FREELY SOLUBLE IN ALCOHOL |
Is pseudoephedrine hydrochloride polar?
Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system….3.1Computed Properties.
| Property Name | Property Value | Reference |
|---|---|---|
| Topological Polar Surface Area | 32.3 Ų | Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07) |
Is pseudoephedrine acidic basic or neutral?
A solution of pseudoephedrine hydrochloride is acidic due to the presence of HB+.
Is ephedrine polar or nonpolar?
The no-polar structure of ephedrine makes this substance more liposoluble than catecholamines.
What is pseudoephedrine HCl?
Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery.
What is pseudoephedrine HCl soluble in?
(1S,2S)-(+)-Pseudoephedrine hydrochloride Properties Freely soluble in water and in ethanol (96 per cent), sparingly soluble in methylene chloride.
What is the difference between phenylephrine HCL and Pseudoephedrine HCL?
Are phenylephrine or pseudoephedrine the same? Phenylephrine and pseudoephedrine are both adrenergic agonists. Phenylephrine has primarily an affinity to only alpha-adrenergic receptors, while pseudoephedrine has an affinity to both alpha- and beta-adrenergic receptors.
How do you dissolve pseudoephedrine?
Add an appropriate amount of 5 N NaOH directly into the flask and shake vigorously to ensure that all pseudoephedrine hydrochloride is dissolved.
What is pseudoephedrine HCL soluble in?
Is pseudoephedrine soluble in methanol?
Note 1: Although pseudoephedrine readily dissolves in methanol, its solubility in chloroform is limited; and in many instances, matrix effects can be problematic.
Is Sudafed a beta agonist?
An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis….Nasal Decongestants.
| Drug | Target | Type |
|---|---|---|
| Pseudoephedrine | Alpha-2A adrenergic receptor | target |
| Pseudoephedrine | Beta-2 adrenergic receptor | target |
What receptors does pseudoephedrine work?
Pseudoephedrine is a sympathomimetic with a mixed mechanism of action, direct and indirect. It indirectly stimulates alpha-adrenergic receptors, causing the release of endogenous norepinephrine (NE) from the granularity of neurons, while it directly stimulates beta-adrenergic receptors [11,12,13].