Can Zejula cause CA125 to rise?
The REVOCAN trial plans to enroll 26 women who have been using Tesaro’s Zejula as a second-line maintenance therapy for at least six months, and who experienced an elevation in the ovarian cancer biomarker CA125. This rise may signal the cancer is progressing while on Zejula.
Can CA125 increase after chemotherapy?
The present investigation was inspired by studies describing a paradoxical increase of tumor markers (CEA, CA 125, and CA 15-3) in the days after chemotherapy of women with breast cancer. If CA 125 increases within days after chemotherapy, the increase may be caused by death of the cancer cells.
What is refractory metastatic cancer?
Cancer that does not respond to treatment. The cancer may be resistant at the beginning of treatment or it may become resistant during treatment.
What is included in FOLFIRI?
A chemotherapy regimen consisting of leucovorin calcium (calcium folinate), 5-fluorouracil, and irinotecan used in the treatment of advanced-stage and metastatic colorectal cancer.
Is FOLFOX a fluoropyrimidine?
5-FU belongs to fluoropyrimidine drugs (Figure 1), which are widely used in the therapy of gastrointestinal cancers including colorectal cancer.
Why is oxaliplatin given before irinotecan?
Our study suggested that irinotecan followed by oxaliplatin-based regimens might be a better chemotherapy treatment option for metastatic colorectal cancer than the reverse sequence given the higher crossover rate and potential overall survival benefit.
What is the chemo drug FOLFIRI?
FOLFIRI is also known as irinotecan de Gramont or irinotecan modified de Gramont. It is a treatment for advanced bowel cancer and other digestive (gastric) cancers.
Can CA 125 go up and down?
So, CA 125 values can and do fluctuate. Major treatment decisions, such as changing or discontinuing treatment, depend on multiple factors that you and your physician will consider. The trend in your CA 125 values is only one of these factors.
What is a good CA 125 level?
The normal value is less than 46 U/mL. If your CA 125 level is higher than normal, you may have a benign condition, or the test result could mean that you have ovarian, endometrial, peritoneal or fallopian tube cancer. Your doctor may recommend other tests and procedures to determine your diagnosis.
What is FOLFIRI chemotherapy?
FOLFIRI is the name of a chemotherapy combination that includes: FOLFIRI is also known as irinotecan de Gramont or irinotecan modified de Gramont. It is a treatment for advanced bowel cancer and other digestive (gastric) cancers.
What is FOLFIRI bevacizumab used for?
Use in Cancer. FOLFIRI-BEVACIZUMAB is used to treat: Colorectal cancer that has metastasized (spread to other parts of the body). This combination may also be used with other drugs or treatments or to treat other types of cancer.
What are the side effects of FOLFIRI?
It is common for people who are treated with FOLFIRI to have mild side effects only. When neutrophils are low, you are at risk of getting an infection more easily. It is important to watch for early signs of infection and tell your healthcare team about them right away.
What is 5FU FOLFIRI used for?
FOLFIRI is a combination of chemotherapy drugs and is also known as irinotecan de Gramont or Irinotecan modified de Gramont. It is a treatment for bowel cancer. These cancer drugs destroy quickly dividing cells, such as cancer cells. You have folinic acid, 5FU and irinotecan into your bloodstream (intravenously).