What is NTCP receptor?
A liver-specific bile acid transporter named the sodium taurocholate cotransporting polypeptide (NTCP) has been identified as the cellular receptor for HBV and its satellite, the hepatitis D virus (HDV).
What is sodium taurocholate Cotransporting polypeptide?
Sodium taurocholate cotransporting polypeptide (NTCP) is a carrier protein in the basolateral membrane of the hepatocyte to uptake bile acids from plasma, playing a crucial role in the enterohepatic circulation of bile acids (Hagenbuch and Dawson, 2004).
Is bile salt and bile acid the same?
Bile salts are made of bile acids that are conjugated with glycine or taurine. They are produced in the liver, directly from cholesterol. Bile salts are important in solubilizing dietary fats in the watery environment of the small intestine. Glyco-bile and tauro-bile acids are also referred to as conjugated bile acids.
What is BSEP transporter?
The bile salt export pump (BSEP) is the major transporter for the secretion of bile acids from hepatocytes into bile in humans. Detailed analysis of these diseases has considerably increased our knowledge about physiology and pathophysiology of bile secretion in humans.
Which is the site of na bile acid cotransport?
liver
Sodium taurocholate cotransporting polypeptide presents in the basolateral compartment of liver cells that reabsorbs bile acid–drug conjugates from the hepatic portal vein and thus complete one enterohepatic circulation cycle.
What is covalently closed circular DNA?
cccDNA (covalently closed circular DNA) is a special DNA structure that arises during the propagation of some viruses in the cell nucleus and may remain permanently there. It is a double-stranded DNA that originates in a linear form that is ligated by means of DNA ligase to a covalently closed ring.
How are bile salts made?
Bile salts are produced in the liver from cholesterol, specifically in pericentral hepatocytes, and their daily production is approximately 350 mg (1). Seventeen enzymes convert cholesterol into bile acids, which are transformed into bile salts by the association with Na+ or K+ ions.
What is the function of sodium taurocholate?
Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.
What are sodium glycocholate and sodium taurocholate?
Sodium glycocholate is a bile salt. It contains a glycocholate. The glycine conjugate of CHOLIC ACID. It acts as a detergent to solubilize fats for absorption and is itself absorbed….4.4Related Compounds.
| Same Connectivity | 14 Records |
|---|---|
| Similar Compounds | 624 Records |
Who needs bile salts?
Bile salts are a primary component of bile and are needed by our bodies to help break down fats, aid digestion, absorb important vitamins, and eliminate toxins. Bile salts are stored in our gallbladders when they’re not being used. If our gallbladders are removed for any reason, it can lead to a bile salt deficiency.
Is cholestasis a disease?
Cholestasis is a liver disease. It occurs when the flow of bile from your liver is reduced or blocked. Bile is fluid produced by your liver that aids in the digestion of food, especially fats. When bile flow is altered, it can lead to a buildup of bilirubin.
What is the function of SLC10A1?
Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011] SLC10A1 (Solute Carrier Family 10 Member 1) is a Protein Coding gene. Diseases associated with SLC10A1 include Hypercholanemia, Familial, 2 and Hepatitis B .
What diseases are associated with the SLC10A1 gene?
Diseases associated with SLC10A1 include Hypercholanemia, Familial, 2 and Hepatitis B . Among its related pathways are Drug Induction of Bile Acid Pathway and Hepatic ABC Transporters . Gene Ontology (GO) annotations related to this gene include bile acid:sodium symporter activity and bile acid transmembrane transporter activity .
How does SLC10A1 s267f variant affect HBV?
SLC10A1 S267F variant influences susceptibility to HBV infection and reduces cholesterol level by impairing bile acid uptake The SLC10A1 Ser267Phe (S267F) variant has been reported to severely inhibit hepatitis B virus (HBV) infection and taurocholate transport activity.
How does hyperosmolarity affect SLC10A1 uptake?
Hyperosmolarity stimulates transporter-mediated insertion of estrone sulfate into the plasma membrane, but inhibits the uptake by SLC10A1 (NTCP). Abnormal Bilirubin Metabolism in Patients With Sodium Taurocholate Cotransporting Polypeptide Deficiency.