What is the basic mechanism of action of fondaparinux?
Fondaparinux selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin. Neutralization of Factor Xa inhibits its activity and interrupts the blood coagulation cascade, thereby preventing thrombin formation and thrombus development.
What is Arixtra used for?
Fondaparinux is used to treat serious blood clots in the legs and/or lungs. It is usually used with another “blood thinner” medication (warfarin). If untreated, blood clots can travel to the lungs, heart, or brain, causing serious (possibly fatal) breathing problems, heart attack, or stroke.
What is the mechanism of action of enoxaparin?
Mechanism of action Enoxaparin binds to and potentiates antithrombin (a circulating anticoagulant) to form a complex that irreversibly inactivates clotting factor Xa. It has less activity against factor IIa (thrombin) compared to unfractionated heparin (UFH) due to its low molecular weight.
What drug class is Arixtra?
Arixtra, a “blood thinner”, belongs to a group of drugs called factor Xa (ten A) inhibitor anticoagulants. These medications work by decreasing the ability of blood to form clots.
What is the injection for blood clots?
Heparin is an anticoagulant medicine given as a shot (injection). Your doctor may have given you low-molecular-weight heparin. Anticoagulants are often called blood thinners. They prevent new blood clots from forming and keep existing clots from getting larger.
Does Arixtra affect platelet count?
Severe thrombocytopenia (platelet counts less than 50,000/mm3) occurred at a rate of 0.2% in patients given Arixtra 2.5 mg in these clinical trials. During extended prophylaxis, no cases of moderate or severe thrombocytopenia were reported.
Is Arixtra safe for pregnancy?
In summary, fondaparinux has proven to be a safe and efficacious alternative anti-coagulant in women with heparin intolerance in pregnancy. Further larger, multicentre studies are required to understand the greater impact of fondaparinux on maternal and fetal well-being.
What is the indication for enoxaparin?
Acute coronary syndromes such as ST-elevation myocardial infarction, Non-ST elevation myocardial infarction, and unstable angina. Deep venous thrombosis (DVT) treatment. Deep venous thrombosis (DVT) prophylaxis. Treatment for pulmonary embolism (PE)