What is the difference between Micronodular and Macronodular cirrhosis?
In the micronodular form (Laennec’s cirrhosis or portal cirrhosis), regenerating nodules are under 3 mm. In macronodular cirrhosis (post-necrotic cirrhosis), the nodules are larger than 3 mm. Mixed cirrhosis consists of nodules of different sizes.
What cells are involved in cirrhosis?
The walls of hepatic sinusoids are lined by three different nonparenchymal cells: liver sinusoidal endothelial cells (LSECs), Kupffer cells (KCs), and hepatic stellate cells (HSCs). Both hepatic parenchymal and nonparenchymal cells are involved in the initiation and progression of liver fibrosis and cirrhosis.
What is Micronodular cirrhosis?
Micronodular cirrhosis corresponds to liver parenchyma in which almost all nodules are smaller than 3 mm. This is the classical “Laennec cirrhosis” caused by chronic alcohol-induced liver injury (Fig. 41.1A) but which is also seen in hemochromatosis, chronic biliary disorders (Fig. 41.1B), and Wilson disease.
What is the most common cause of Micronodular cirrhosis?
The most common cause for this is chronic alcoholism. The process of cirrhosis develops over many years.
Which molecule is responsible for liver disease?
Excessive hepatocyte iron causes hepatitis and cirrhosis.
Can liver fibrosis reversible?
Recent studies indicate that liver fibrosis is reversible when the causative agent (s) is removed. Understanding of mechanisms of liver fibrosis regression will lead to the identification of new therapeutic targets for liver fibrosis.
What stage of cirrhosis does edema occur?
Stage 3 cirrhosis involves the development of swelling in the abdomen and advanced liver scarring. This stage marks decompensated cirrhosis, with serious complications and possible liver failure.
What happens to liver cells during cirrhosis?
Cirrhosis is a late-stage liver disease in which healthy liver tissue is replaced with scar tissue and the liver is permanently damaged. Scar tissue keeps your liver from working properly. Many types of liver diseases and conditions injure healthy liver cells, causing cell death and inflammation.