What is camptothecin used for?
Camptothecin, an quinolone alkaloid, is used as a chemotherapeutic agent in the treatment of leukemia (Jones et al., 1997). Camptothecin complexes with type I DNA topoisomerase inhibiting both cleavage and religation reactions of DNA replication thus arresting growth of L.
Is camptothecin an antibiotic?
Currently, topoisomerase inhibitors hold a prominent place among antibiotics and anticancer drugs in active medical use, as inhibitors like doxorubicin (anthracycline, TopII inhibitor), etoposide (TopII inhibitor), ciprofloxaxin (fluoroquinolone, TopII inhibitor), and irinotecan (camptothecin derivative, TopI inhibitor …
How is camptothecin administered?
How This Drug Is Given: This medication is given by infusion through a vein (intravenously, IV). There is no pill form of this medication. Irinotecan is an irritant.
What type of drug is oxaliplatin?
Oxaliplatin is a type of chemotherapy drug. It is also called Eloxatin. It’s a treatment for bowel cancer and some other types of cancer. You usually have oxaliplatin in combination with other chemotherapy drugs.
Is camptothecin FDA approved?
Four CPT analogues have been approved and are used in cancer chemotherapy today, topotecan, irinotecan, belotecan, and trastuzumab deruxtecan. Camptothecin has also been found in other plants including Chonemorpha fragrans….Camptothecin.
| Clinical data | |
|---|---|
| show IUPAC name | |
| CAS Number | 7689-03-4 |
| PubChem CID | 2538 |
| DrugBank | DB04690 |
Is camptothecin cytotoxic?
Camptothecin is a specific topoisomerase I poison and is highly cytotoxic to eukaryotic cells. In the present study, we show, using a pulse field gel electrophoresis assay, that camptothecin induces DNA double strand breaks (DSBs) specifically in newly replicated DNA.
What cancers does oxaliplatin treat?
Oxaliplatin is a chemotherapy drug used to treat bowel cancer, stomach cancer, pancreatic cancer and cancer of the oesophagus.
What type of compound is camptothecin?
alkaloid
Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I.
How is camptothecin made?
It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used in traditional Chinese medicine. It has been used clinically more recently in China for the treatment of gastrointestinal tumors.
Is camptothecin an alkaloid?
Camptothecin is an alkaloid first isolated from the stem wood of the tree Camptotheca acuminata (Nyssaceae), and has potent antitumor activity. Camptothecin acts by inhibiting the enzyme topoisomerase-I, which is responsible for relaxing supercoils that are generated during transcription and DNA replication.