What is the SCN5A gene?
The SCN5A gene encodes the alpha subunit of the main cardiac sodium channel Nav1.5. This channel predominates inward sodium current (INa) and plays a critical role in regulation of cardiac electrophysiological function.
What are the main characteristics of Brugada syndrome?
Signs and symptoms that may be associated with Brugada syndrome include: Dizziness. Fainting. Gasping, labored breathing, particularly at night.
Can you live a long life with Brugada syndrome?
Brugada syndrome may be a major cause of sudden cardiac death in men under 40. People with Brugada syndrome on average die between the ages of 26 to 56 years, with an average age of 40 years. If treated appropriately, patients can have a normal lifespan.
Does Brugada syndrome go away?
There’s currently no cure for Brugada syndrome, but there are things you can do to reduce your risk of experiencing serious problems. If your doctor thinks your risk of developing a dangerously fast heartbeat is low, you might not need any treatment at first.
Can Brugada syndrome be cured?
Currently, there is no cure for Brugada syndrome. However, there are ways to effectively manage the disease, including lifestyle changes and avoiding certain medications. In some patients, an implanted cardioverter defibrillator can help prevent sudden death related to Brugada syndrome.
What does SCN5A stand for?
SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5) is a Protein Coding gene. Diseases associated with SCN5A include Sudden Infant Death Syndrome and Long Qt Syndrome 3.
What causes Romano Ward syndrome on the cellular level?
Mutations in the KCNQ1, KCNH2, and SCN5A genes are the most common causes of Romano-Ward syndrome. These genes provide instructions for making proteins that form channels across the cell membrane. These channels transport positively charged atoms (ions), such as potassium and sodium, into and out of cells.
What does Brugada syndrome feel like?
Symptoms of Brugada syndrome can include: Ventricular tachyarrhythmia (a fast, irregular heart rhythm that begins in the lower chambers of the heart) Fainting (syncope) Heart palpitations (can feel like a fluttering or a flip-flopping in the chest)
Can you exercise with Brugada syndrome?
There are insufficient data on the risks of exercise in Brugada syndrome to make recommendations for exercise, but the observations that exercise can worsen the ST abnormalities in Brugada and produce ventricular arrhythmias suggest that patients with Brugada syndrome should be restricted from vigorous exercise.
Is Long QT syndrome dominant or recessive?
LQTS is typically inherited in an autosomal dominant manner. An exception is LQTS associated with sensorineural deafness (known as Jervell and Lange-Nielsen syndrome), which is inherited in an autosomal recessive manner. Most individuals diagnosed with LQTS have an affected parent.