What is a high-shear granulator?
A high-shear granulator or high-shear mixer uses a rotating impeller or high-speed rotor (or both) to create flow and shear. High-shear granulation is an effective way to turn powders into dense granules for tableting or coating.
How does a high-shear granulator work?
High shear granulation is a shaping process for granulation that has been enhanced for application in the pharmaceutical industry. A binder liquid is fed to the powder particles in a closed container with blending tools and a chopper. Dense granules are formed through the liquid and solid bridges that result.
What is high-shear mixing technique?
A high shear mixer uses a rotor, rotating at high speeds, to direct material outwards towards a stationary stator and thus shear the material. Variable rotor speeds provide the ability to uniquely tailor the amount of shear energy for each application.
What are the advantages of high shear granulation *?
The granulator produces reproducible less friable granules with a uniform particle size distribution. 5. High-shear granulator minimizes the exposure of drug dust to workers due to reduced process dust generation.
What is high speed granulator?
The PerMix PDI series High Speed Mixer, also called Mixer Granulator, Wet Granulator, or High Shear Mixer Granulator, is an efficient and versatile blending machine for mixing of dry powders, or granulating with the addition of liquid binder, within a very short time and with excellent cleaning abilities.
Which blender works with high-shear stress?
Ribbon Blender, High Shear Mixer Granulator, Double Cone Blender.
What is high-shear and low shear?
High shear, or very forceful, mixing processes uses high-speed impellers, and low shear mixing processes use flow, turbulence, and rotational force to combined miscible goods.
How does a high-shear homogenizer work?
High shear homogenizers operate at a high velocity to pull, push and break apart a sample. Thus, they generate substantially smaller particles than some other kinds of homogenizers and are an especially good option for the following applications: Particle Size Reduction/Sub-Micron Homogenization.
How does a fluid bed granulator work?
The fluid bed granulation process (also known as agglomeration) involves suspending particles in an air stream and spraying a liquid from the top of the system down onto the fluidized bed (top-down spray). Particles in the path of the spray get slightly wet and become sticky.